Colloidal particles are an important vector for the transport of contaminants in karst aquifers, characterized by a high degree hydrologic variability. Understanding this heterogeneity and hydrogeological functioning is particular importance water management strategies. Until now, parameters were mostly determined injection solutes or surrogates natural sediments. But suspended easier to analys...

Bitcoin system (or Bitcoin) is a peer-to-peer and decentralized payment that uses cryptocurrency named bitcoins (BTCs) was released as open-source software in 2009. Unlike fiat currencies, there no centralized authority or any statutory recognition, backing, regulation for Bitcoin. All transactions are confirmed validity by network of volunteer nodes (miners) after collective agreement subseque...

In advanced Biliary Tract Cancers (aBTCs), RAF alterations define a rare subset of patients (pts) and may predict response to inhibition the BRAF/MEK/ERK signaling pathway. BRAF mutations are grouped in activating RAS-independent (muts) as monomers (class I) or dimers II) RAS-dependent with impaired kinase activity kinase-dead III). Moreover, BRAF+MEK inhibitors have been FDA-approved for pts a...

Abstract The Mediterranean area concentrates the world’s largest production of olive oil. oil industry represents, in this basin, one leading sectors agri-food economy. Olive mill water (OMW) is principal waste effluent produced by industry. Due to its high pollution load, aqueous by-product cannot be directly disposed domestic wastewater treatment plants (especially those with a biological uni...

We collected and analyzed breakthrough curve (BTC) data to identify the parameters controlling transport from a series of undisturbed fully saturated soil cores and a field test at the Shale Hills Critical Zone Observatory in central Pennsylvania. The soil cores were collected in a continuous hole extending across the soil profile vertically at one location to quantify how solute transport beha...

Biliary tract cancers (BTCs) are rare malignancies with a poor prognosis and scarce therapeutic strategies. The BRCAness phenotype has been shown to correlated good response platinum-based chemotherapy PARP inhibitors in several oncologic setting, but its significance BTC is already unknown. Tissue specimens of patients treated have analyzed through the FOUNDATION Cdx technology. mutated group ...

soil using Cl as a tracer in a 5 mM solution of CaCl2. The AEC ranged from 0.01 to 1.86 cmolc kg 1 with an Many studies have shown that subsoils in the Piedmont region of average value of 0.68 cmolc kg 1. Retardation coeffithe southeastern USA have anion exchange capacity (AEC) and can adsorb anions such as nitrate (NO 3 ). Groundwater discharging to cients were determined from the BTC data and...

Biliary Tract Cancers (BTC) patients (pts) have poor prognosis and limited therapeutic options, but there is increasing evidence for biomarker-directed therapy, with several potentially actionable molecular targets FDA-approved drugs. ESMO ASCO recommends the use of tumour multigene next generation sequencing (NGS) BTC. This was a multicentric study assessing real-life clinical actionability al...

ventional methods to investigate colloid transport often involve column studies. Here, colloid concentrations are A new experimental approach and complementary model analysis measured at the column effluent or at selected points are presented for studying colloid transport and fate in porous media. The experimental approach combines high precision etching to create along the column length. Unfo...

Biliary tract cancers (BTCs) are rare and aggressive malignancies. The current standard of care for advanced BTC is gemcitabine (GEM), cisplatin, durvalumab. Although there no firmly established second-line treatment, regimens such as FOLFOX, XELOX, FOLFIRI, XELIRI, GEM, GEM/nab-paclitaxel, capecitabine have activity. Nal-IRI contains IRI free base encapsulated in liposome nanoparticles which s...