Bernard Le Foll and Isabelle Boileau 1 Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada 2 Alcohol Research and Treatment Clinic, Addictions Program, CAMH, Toronto, Ontario, Canada 3 Departments of Psychiatry, Pharmacology, Family and Community Medicine and Institute of Medical S...

OBJECTIVE To determine whether central serotonin receptors are involved in the pathophysiology of non-ulcer dyspepsia. DESIGN Between subjects study of solid phase gastric emptying and prolactin response to buspirone challenge. SUBJECTS 12 patients fulfilling criteria for non-ulcer dyspepsia and 12 age and sex matched controls. MAIN OUTCOME MEASURES Solid phase gastric emptying measured b...

Generalized anxiety disorder (GAD) is characterized by chronically persistent worry and therefore requires effective long-term treatment. This article reviews the benefits and risks associated with various pharmacologic and psychological therapies to assess their ability to achieve the elimination of GAD symptomatology and restoration of normal function. Psychotherapeutic approaches such as app...

BACKGROUND AND PURPOSE Neuroprotective effects of induced hypothermia depend on its time point of initiation after acute brain injury. Preliminary studies in cardiac arrest patients indicate that rapid infusion of ice cold saline (ICS) is safe and effective for induction of hypothermia. We investigated its use in patients with acute ischemic stroke (AIS). METHODS Patients (n=10) with AIS were...

Serotonin is known to inhibit food and water intake. However, the effect of its injection into nucleus caudatus on food and water intake is not known. In the present study, serotonin hydrochloride, buspirone (the serotonin 5-HT1A agonist) and ondensetron (the 5HT3 antagonist) were injected into nucleus caudatus through stereotaxically implanted cannulae in three different dosages (1, 2 and 5 mi...