When gram-negative bacterial lipopolysaccharides (LPS) are injected intravenously into the rabbit or rat, they bind to plasma lipoproteins, particularly high density lipoproteins (HDL). The present studies were performed to examine the mechanisms by which LPS-HDL complexes are removed from the circulation and taken up by various tissues. Our approach was to compare the sites of specific tissue ...

BACKGROUND Lipid alterations have been described in sickle cell anemia (SCA), but their association with the disease severity is not fully understood and correlation nutritional status of this population has widely studied. OBJECTIVES This study aimed to assess lipid profile its relation status, including anthropometric characteristics daily macronutrient intake, biomarkers adults SCA a steady ...

Background and aimsApolipoprotein (apo) C1 is a 6.6 kDa protein associated with HDL VLDL. ApoC1 alters triglyceride clearance, it also favors cholesterol accumulation in HDL, especially by inhibiting CETP human plasma. Apart from studies mice, which lack CETP, the impact of apoC1 on atherosclerosis animal models expressing like humans, not known. This study aimed at determining net effect rabbi...

Hepatic lipase activity (HLA) is a determinant of HDL levels, and a polymorphism in the hepatic lipase gene (LIPC) promoter (C-514T) has been hypothesized to account for higher HDL in blacks and Japanese compared with whites. To determine whether the polymorphism contributes to ethnic differences in HDL, we compared LIPC allele frequencies and HLA in Japanese American (JA; n = 84), black Americ...

It has been reported previously that the particle size distribution of discoidal, reconstituted HDL (r-HDL) changes dramatically during incubation in vitro with cholesteryl ester transfer protein (CETP). The present study was undertaken in order to determine whether these changes are influenced by the apolipoprotein composition of the r-HDL. Two preparations of r-HDL that contained egg phosphat...

Abstract Background Research and clinical studies have established a pivotal role of inflammation in the development progression both cardiac vascular diseases, responsive to injurious factors such as smoking, hypertension, dyslipidemia, hyperglycemia. This study analyzed association various lipids, HbA1c glucose with high-sensitivity CRP (hs-CRP), marker low-grade chronic inflammation, communi...

BACKGROUND Recent data suggest that high-density lipoprotein cholesterol (HDL-C) levels are likely not in the causative pathway of atheroprotection, shifting focus from HDL-C to its subfractions and associated proteins. This study's goal was to determine which HDL phenotype was the better predictor of carotid artery disease (CAAD). METHODS AND RESULTS HDL-2 and HDL-3 were measured in 1725 par...

BACKGROUND We examined the predictive value of various clinical and biochemical markers for angiographically defined coronary artery disease (aCAD). Specifically, we assessed the value of the ratio of plasma triglyceride (TGs) to HDL-cholesterol (HDL-C) and the fractional esterification rate of cholesterol in plasma depleted of apolipoprotein B (apoB)-containing lipoproteins (FER(HDL)), a funct...