Abstract The condensation of tacrine aminopolymethylene derivatives with diethyl (ethoxymethylidene)malonate led to the new hybrid compounds—conjugates, which were effective inhibitors acetylcholinesterase (AChE) (IC 50 up 0.538 μM) and butyrylcholinesterase 0.0314 μM). They can displace propidium iodide from peripherical anionic site AChE at level reference drug donepezil demonstrate a weak an...

A butyrylcholinesterase, purified from porcine parotid glands, behaved as a single component in sedimentation velocity and sedimentation equilibrium centrifugation and migrated as a single esterase in starch gel electrophoresis. The molecular weight of the enzyme was estimated to be 368,000. Amino acid analysis showed a high proline content (7.6%) and the presence of two unidentified components...