Several esters of 4-methylumbelliferone and 2-naphthol were synthesized and examined as possible spectrofluorimetric titrants for bovine alpha-chymotrypsin, trypsin, thrombin, Factor Xa and for subtilisin Novo. 4-Methylumbelliferyl p-guanidinobenzoate hydrochloride (MUGB) is a satisfactory titrant for alpha- and beta-trypsin, thrombin and Factor Xa and 4-methylumbelliferyl p-(NNN-trimethylammon...

Bornyl caffeate (1) was previously isolated by us from Valeriana (V.) wallichii rhizomes and identified as an anti-leishmanial substance. Here, we screened a small compound library of synthesized derivatives 1-30 for activity against schistosomula of Schistosoma (S.) mansoni. Compound 1 did not show any anti-schistosomal activity. However, strong phenotypic changes, including the formation of v...

Novel amylose ester derivatives were synthesized and their chiral recognition abilities as chiral stationary phases for highperformance liquid chromatography were evaluated. Compared with amylose benzoate derivatives, cinnamate derivatives showed a higher chiral recognition ability and some racemates could be efficiently resolved. The recognition abilities of these derivatives varied significan...

As demonstrated by means of DNA nanoconstructs, as well as DNA functionalization of nanoparticles and micrometre-scale colloids, complex self-assembly processes require components to associate with particular partners in a programmable fashion. In many cases the reversibility of the interactions between complementary DNA sequences is an advantage. However, permanently bonding some or all of the...

The stability of porous coordination polymers during an electrochemical reaction could be improved by introducing supporter materials. An I3O0-type inorganic hybrid electrocatalyst, cobalt cinnamate, supported on reduced graphene oxide (rGO) was successfully prepared for oxygen evolution reaction. electrocatalytic activity and cinnamate(catalyst)/rGO composite were significantly due to the stro...

It is not known how plants make the benzenoid ring of ubiquinone, a vital respiratory cofactor. Here, we demonstrate that Arabidopsis thaliana uses for that purpose two separate biosynthetic branches stemming from phenylalanine and tyrosine. Gene network modeling and characterization of T-DNA mutants indicated that acyl-activating enzyme encoded by At4g19010 contributes to the biosynthesis of u...

Table 1: Quantitation over all tumor (for MYC) and liver (for healthy) voxels for mice in which MCT inhibition experiments were performed. Note: the pyruvate category includes pyruvate-hydrate. As shown by the data above, in all cases, alanine and lactate decreased after 4-CIN administration. Introduction: Development of hyperpolarized technology utilizing dynamic nuclear polarization has enabl...