Kim, Yuri V., Francescopaolo Di Cello, Coryse S. Hillaire, and Kwang Sik Kim. Differential Ca signaling by thrombin and protease-activated receptor-1-activating peptide in human brain microvascular endothelial cells. Am J Physiol Cell Physiol 286: C31–C42, 2004. First published August 27, 2003; 10.1152/ajpcell.00157. 2003.—Thrombin and related protease-activated receptors 1, 2, 3, and 4 (PAR1–4...

Background: Dental caries is one of the most common oral diseases in pre-school children. Several factors can affect caries process. Aim of this study was comparison of some of the chemical properties of saliva such as total antioxidant capacity, total protein, pH, nitric oxide level in caries free (CF), and caries active (CA) children.<...

The concentration of cytoplasmic Ca(2+) regulates the contractile state of smooth muscle cells and tissues. Elevations in global cytoplasmic Ca(2+) resulting in contraction are accomplished by Ca(2+) entry and release from intracellular stores. Pathways for Ca(2+) entry include dihydropyridine-sensitive and -insensitive Ca(2+) channels and receptor and store-operated nonselective channels perme...

We investigated the concentration- and Ca(2+)-dependent effects of CaM mutants, CaM(12) and CaM(34), in which Ca(2+)-binding to its N- and C-lobes was eliminated, respectively, on the Ca(V)1.2 Ca(2+) channel by inside-out patch clamp in guinea-pig cardiomyocytes. Both CaM(12) and CaM(34) (0.7-10muM) applied with 3mM ATP produced channel activity after "rundown". Concentration-response curves we...

This research work has been carried out to study the effect of different Ca contents (0.5, 1.0, 1.5, 2.0 and 3.0) on the microstructure and porosity content of ZK60 alloys. The samples were examined by using optical and scanning electron microscopy (SEM) to evaluate the modification efficiency of the alloy with different Ca concentrations. The cast specimens were modified, homogenized and extru...

Background: The aim of present study was to estimate the levels of some minerals ( Zn, Se , Ca , Mg , Na and K ).Also relationships between mentioned components and some sperm parameters and the infertility period were studied as well. Materials and Methods: This study was performed on human semen specimens obtained from Asthenospermic patients (101 specimens) and Normospermic males (61 specime...

A study was done to determine whether broilers can regulate Ca intake when limestone is provided separately or mixed with a crumbled feed of variable Ca and P content, and the influence of this on performance and apparent ileal digestibility (AID) of Ca and P (AIDP). Twelve crumbled diets were fed from 10 to 20 d of age (8 replicates, 8 broilers/replicate). Diets A to D contained 0.28% nonphyta...

The role of Na(+)/Ca(2+) exchange in regulating intracellular Ca(2+) concentration ([Ca(2+)](i)) in isolated smooth muscle cells from the guinea pig urinary bladder was investigated. Incremental reduction of extracellular Na(+) concentration resulted in a graded rise of [Ca(2+)](i); 50-100 microM strophanthidin also increased [Ca(2+)](i). A small outward current accompanied the rise of [Ca(2+)]...

the eye becomes opaque resulting in severe visual impairment. Numerous factors have been implicated in the etiology of cataracts, including genetic factors, diabetes, smoking, nutrition, the cumulative effect of X-rays, ultraviolet irradiation, and alteration in both endocrine and enzymatic equilibrium. Cataractous lenses have an altered distribution of the intracellular ionic environment. In h...