background: release of vascular endothelial growth factor (vegf) by ovaries in response to hcg administration is one of the main mechanisms of ovarian hyper stimulation syndrome. since dopamine/dopamine receptor2 (dp-r2) pathway activity -mediated by vegf/ vascular endothelial growth factor receptor 2 (vegfr-2) signaling-, is associated with angiogenic events, dopamine agonists were used for th...

BACKGROUND Polycystic ovary syndrome (PCOS) is characterized by abnormal gonadotrophin secretion, in particular an elevated serum concentration of LH, depressed FSH, and an LH/FSH ratio of >or =2. Mild, transient hyperprolactinaemia is frequently associated with PCOS (30% of patients); furthermore, it can be observed during the late follicular and luteal phases of both natural and stimulated cy...

Hannah-Shmouni F, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-222411 Description A 29-year-old woman with neurofibromatosis 1 (NF1) due to NF1 gene deletion presented for evaluation of long-standing secondary amenorrhea. She noted increasing growth of her hands and feet, inability to fit her ring on her fingers and increasing shoe size (currently US size 12). Physical examination revealed co...

The neuroendocrine response to sexual activity in humans is characterized by a pronounced orgasm-dependent increase of plasma levels of prolactin. In contrast to the well-known inhibitory effects of chronic hyperprolactinemia on sexual drive and function, the impact of acute prolactin alterations on human sexual physiology is unknown. Therefore, this study was designed to investigate the effect...

background: the purpose of this study was to compare the three different strategies, intravenous (iv) hydroxylethyl starch (hes), iv human albumin (ha), and oral cabergoline (cb) in the prevention of ovarian hyperstimulation syndrome (ohss). materials and methods: in this prospective randomized clinical trial, 91 women at high risk of developing ohss were allocated into the three groups, group ...

Dear Editor, Rheumatoid arthritis (RA) is a chronic systemic in-flammatory disorder affecting about 1% of the world population. 1 In recent years, biologic agents were introduced for many aspects of medicine including RA, but their cost and potential side effects prohibited its widespread use. Dopamine agonists such as bromocriptine and cabergoline decreased the prolactin synthesis and secretio...

Pituitary adenomas are a common intracranial neoplasm, usually demonstrating a benign phenotype. They can be classified according to pathological, radiological or clinical behaviour as typical, atypical or carcinomas, invasive or noninvasive, and aggressive or nonaggressive. Prolactinomas account for 40-60% of all pituitary adenomas, with dopamine agonists representing the first-line treatment ...