Non-keratinocyte cutaneous malignancies including breast cancer metastasis and melanoma in situ are often poor surgical candidates due to their anatomical location, size the morbidities associated with surgery. Imiquimod, a toll-like receptor 7 agonist, is used for treatment of these malignancies, which activates innate immunity skin. However, imiquimod’s modest effect on activation adaptive li...

BACKGROUND Probably related to immune dysfunction, psoriasis vulgaris is a chronic, painful, disfiguring and disabling dermatological disease, carrying an increased risk of serious comorbidities. Current conventional therapies can be costly, show risks of side effects and have limited efficacy, with relapse common on treatment cessation. Chinese herbal medicine is effective in treating psoriasi...

Active and less toxic vitamin D analogs could be useful for clinical applications. In the present study, the antitumor effects of two new synthetic analogs of vitamin D, namely PRI-2202 (24R calcipotriol) and PRI-2205 (5, 6-trans calcipotriol), were evaluated. Since the analogs PRI-2202 and PRI-2205 administered alone inhibited tumor growth only slightly, they were applied in a combined therapy...

BACKGROUND Plaque psoriasis has a relatively high prevalence in adolescence, resulting in a significant impact on quality of life, including social interactions. OBJECTIVES The primary objective was to assess the safety of once-daily application of fixed-combination calcipotriol plus betamethasone dipropionate gel in adolescent scalp psoriasis. Assessment of efficacy was a secondary objective...

Alopecia areata (AA) is an inflammatory hair loss of unknown etiology. AA is chronic and relapsing, and no effective cure or preventive treatment has been established. Vitamin D was recently reported to be important in cutaneous immune modulation as well as calcium regulation and bone metabolism. It is well known that areata is common clinical finding in patients with vitamin D deficiency, vita...