Of 50 patients with urinary calculi, upper tract stones were common between 15-44 and lower tract stones between 0-14 and above 44 years of age. Urinary calculi contained calcium, phosphate, oxalate, urate/uric acid, ammonium, magnesium and carbonate. The frequency of occurrence of each of these radicals in sixty stones was 93.33, 83.33, 61.67, 51.67, 25.00 and 13.33% respectively. Five (27.78%...

BACKGROUND AND OBJECTIVES Primary hyperoxaluria types I and II (PHI and PHII) are rare monogenic causes of hyperoxaluria and calcium oxalate urolithiasis. Recently, we described type III, due to mutations in HOGA1 (formerly DHDPSL), hypothesized to cause a gain of mitochondrial 4-hydroxy-2-oxoglutarate aldolase activity, resulting in excess oxalate. DESIGN, SETTING, PARTICIPANTS, & MEASUREMEN...

Considering the widespread occurrence of oxalate in nature and its broad impact on a host of organisms, it is surprising that so little is known about the turnover of this important acid. In plants, oxalate oxidase is the most well studied enzyme capable of degrading oxalate, but not all plants possess this activity. Recently, an Acyl Activating Enzyme 3 (AAE3), encoding an oxalyl-CoA synthetas...

The majority of human kidney stones are comprised of multiple calcium oxalate monohydrate (COM) crystals encasing a calcium phosphate nucleus. The physiochemical mechanism of nephrolithiasis has not been well determined on the molecular level; this is crucial to the control and prevention of renal stone formation. This work investigates the role of phosphate ions on the formation of calcium oxa...

Phytate and mineral cations are both considered as important dietary factors for inhibiting the crystallisation of calcium oxalate kidney stones in susceptible individuals. In this paper, the phytate and mineral composition of whole bran cereals (wheat, barley and oat) and legumes were determined together with their soluble and insoluble oxalate concentrations in order to investigate the effect...

Amorphous calcium oxalate nanoparticles with sizes of ≈10 nm were synthesized at room temperature by hydrolysis of dimethyl oxalate from ethanolic solution.

To study the effect of high osmotic pressure milk formula on renal calcium oxalate crystallization induced by calcium oxalate. 40 SD rats were randomly divided into four groups: NC, MC, LOM and HOM group. For model preparation, MC, LOM and HOM were treated with 1% Ethanediol in the water combined with 2% ammonium chloride (2ml/day) intragastrically administration. The rats in LOM and HOM were i...

Although often supersaturated with mineral salts such as calcium phosphate and calcium oxalate, normal urine possesses an innate ability to keep them from forming harmful crystals. This inhibitory activity has been attributed to the presence of urinary macromolecules, although controversies abound regarding their role, or lack thereof, in preventing renal mineralization. Here, we show that 10% ...

A severe degree of hypotension in children followed the intravenous administration of codeine phosphate in several case reports—histamine release was its presumed root cause [1–3]. We also report cardiovascular collapse following accidental bolus intravenous injection of 30 mg (74 μmol) codeine phosphate, but it was associated with a surprising profound degree of hypocalcaemia. A quantitative a...

Objective Calcium oxalate crystals are found in majority of kidney stones with calcium oxalate monohydrate (COM) as one of the primary types of kidney stones. Various methods of treatment exist, including herbal treatment in the Philippines that uses the medicinal herb Blumea balsamifera (B. balsamifera). Methods The effect of B. balsamifera extract on the morphology of calcium oxalate crysta...