background :many breast cancer tumor suppressor genes have been reported to undergo hypermethylation, including er, rassf1a, hic, cdh1, gspt1, apc, twist and ccnd2. we first determined the promoter methylation of the above eight tumor suppressor genes as epigenetic markers of breast cancer in three cell lines with different er status. methods : this study was an experimental study performed on ...

The relationship between cancer and iron metabolism has received more attention, but there is less research on nutritional support to improve the inflammatory status of patients by regulating metabolism. A survey was conducted involving 90 with lung cancer. control group given routine hospitalization diet oral nutrition supplement (ONS) nutrient solution basis diet. It lasted for 2 weeks. chang...

Background and Objective:Determination of HER2 gene is crucial in breast carcinoma management and prognosis, as HER2 alterations are linked to a shorter disease-free period, overall survival and resistance to tamoxifen anti-estrogen therapy and other chemotherapy regimens, regardless of the nodal or hormone receptor status. This study aimed to...

BACKGROUND We investigated the risk of cancer mortality according to obesity status and metabolic health status using sampled cohort data from the National Health Insurance system. MATERIALS AND METHODS Data on body mass index and fasting blood glucose in the sampled cohort database (n=363,881) were used to estimate risk of cancer mortality. Data were analyzed using a Cox proportional hazard ...

The prognosis of breast cancer in pre-menopausal women is very variable and dependent on the interactions several biological factors. androgen receptor (AR) could be among prognostic variables related to survival although data scarce. aim study was examine relationship between expression outcomes estrogen (ER)-positive invasive carcinoma patients. We assessed AR ER-positive carcinomas correlate...

metabolomics studies provide useful information about health and disease status. metabolite based investigations on various cancers is a powerful approach to diagnosis, prognosis and therapy of cancer diseases. recently by using advanced analytical techniques such as nmr and ms and its hyphenation methods, global metabolic profiling of diseases has been possible. it is predictable that internat...

To prove clinical benefits of cancer vaccine is currently difficult, except for one phase III trial has documented improved overall survival with the vaccine, Sipuleucel-T, although induction of anti-tumor immune responses through cancer vaccine is theoretically promising and would be straightforward. In contrast, immune checkpoint blockade with anti-CTLA4 mAb and anti-PD-1 mAb has demonstrated...

The status of RB1 in cancer may help us determine the optimal therapeutic approach to patients [...]

The currently available scientific evidence attests that mammographic screening and quality treatment have been able to reduce mortality attributable to breast cancer. Although screening is not without risks, population-based screening has clear advantages over opportunistic detection. Following the Council of the European Union's "Recommendations on cancer screening", all the regional Autonomo...