OBJECTIVE(S) The ongoing increasing antibiotic resistance is one of the biggest challenges faced by global public health. The perennial need for new antimicrobials against a background of increasing antibiotic resistance in pathogenic and opportunistic microorganisms obliges the scientific community to constantly develop new drugs and antimicrobial agents. Lichens are known prolific sources of ...

The aim was to investigate the antifungal effectiveness and some of pharmacological properties of essential oils (EOs), which had not yet been thoroughly studied in the planned scope. We first evaluated MIC/MFC of sixteen EOs against C. albicans ATCC 10231. Then, five most active EOs were tested, using 50 clinical Candida spp. strains and additional reference C. albicans ATCC 90028 strain. The ...

OBJECTIVE To evaluate the in vitro antimicrobial activity of the Eucalyptus globulus essential oil, and of the xylitol and papain substances against the following microorganisms: Pseudomonas aeruginosa; Samonella sp.; Staphylococus aureus; Proteus vulgaris; Escherichia coli and Candida albicans. METHOD The in vitro antimicrobial evaluation was used by means of the agar diffusion test and eval...

Oropharyngeal candidiasis is the most common opportunistic fungal infection in individuals infected with human immunodeficiency virus. CD4+ lymphocytes count and the quantification of viral RNA in blood plasma have been found to be the main markers of HIV disease progression. The present study was conducted to evaluate Candida sp. diversity in the oral cavity of HIV-infected patients and to det...

Recent epidemiological surveys have demonstrated an important increase in nosocomial infections among which Candida sp. plays an increasingly prominent role. Candida is now involved in about 10% of all septicemia and leads to a very high mortality rate in immunodepressed patients. Clinical studies show that any modification of the host immune status can facilitate the proliferation of endogenou...

Candida spp. are among the most common nosocomial fungal pathogens and are notorious for their propensity toward biofilm formation. When growing on a medical device or mucosal surface, these organisms reside as communities embedded in a protective matrix, resisting host defenses. The host responds to Candida biofilm by depositing a variety of proteins that become incorporated into the biofilm m...

A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam's structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-resistant Candida albicans (MIC = 4 μg/mL,...

Isolation and identification of Candida spp. and determination of their antifungal susceptibilities that cause mycotic mastitis in cattle in Tekirdag province and its counties in Marmara Region were aimed in this research. 100 mastitis milk samples were used in the study. Microorganisms isolated as Candida spp. were identified by API 20C AUX rapid identification kit. Antifungal susceptibility r...