نتایج جستجو برای: cantab
تعداد نتایج: 284 فیلتر نتایج به سال:
Psychiatric disorders such as schizophrenia are commonly accompanied by cognitive impairments that are treatment resistant and crucial to functional outcome. There has been great interest in studying cognitive measures as endophenotypes for psychiatric disorders, with the hope that their genetic basis will be clearer. To investigate this, we performed a genome-wide association study involving 1...
Prolonged stress causes dysregulation in the hypothalamic-pituitary-adrenal axis and may contribute to the pathogenesis of major depressive disorder (MDD). MDD is associated with pathological changes in several brain regions, particularly the prefrontal cortex and hippocampus. Evidence from animal research suggests that one of the earliest signs of pathological change after exposure to stress i...
Mild cognitive impairment (MCI) patients report memory problems greater than those normally expected with ageing, but do not fulfil criteria for clinically probable Alzheimer's disease. Accumulating evidence demonstrates that impaired performance on the Paired Associates Learning (PAL) test from the Cambridge Neuropsychological Test Automated Battery (CANTAB) may be sensitive and specific for e...
Background Genetic mosaicism is only detected occasionally when there are no obvious health or developmental issues. Most cases concern healthy parents in whom mosaicism is identified upon targeted testing of a genetic defect that was initially detected in their children. A germline genetic defect affecting the euchromatin histone methyltransferase 1 (EHMT1) gene causes Kleefstra syndrome, whic...
Psychiatric disorders such as schizophrenia are commonly accompanied by cognitive impairments that are treatment resistant and crucial to functional outcome. There has been great interest in studying cognitive measures as endophenotypes for psychiatric disorders, with the hope that their genetic basis will be clearer. To investigate this, we performed a genome-wide association study involving 1...
Objective: The aim of this study is to investigate the effects childhood sexual abuse (CSA) on decision-making, facial emotion recognition, and clinical presentation borderline personality disorder (BPD). In addition, it was examined whether certain cognitive impairments could be worsened by presence CSA. Method: Eighteen sexually abused BPD patients, 18 patients with without CSA, 35 healthy co...
BACKGROUND Cognitive deficits associated with mood disorders, especially bipolar disorder, have been the focus of limited systematic investigation. METHODS We tested 35 bipolar (21 in depressed state and 14 in mixed or manic state) and 58 nonbipolar depressed consecutively admitted young adult inpatients and 51 matched healthy individuals on the Cambridge Neuropsychological Test Automated Bat...
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