Receptor activity modifying protein-3 (RAMP-3) has been shown to complex with the calcitonin receptor-like receptor, establishing a functional receptor for adrenomedullin (AM). AM exhibits potent antiproliferative and antimigratory effects on rat mesangial cells (RMCs). In this study we investigated the effect of platelet-derived growth factor (PDGF) on RAMP-3 expression in RMCs. We show here t...

Three hundred six crossbred steers (703 ± 1 lb) were used to determine effects of adapting steers to a finishing diet using RAMP for 14 to 30 d on steer performance and carcass characteristics. RAMP treatments were compared to a traditional step-up procedure (CON) utilizing an initial concentration (DM-basis) of 32.5% steam-flaked corn (SFC), 45% alfalfa hay (ALF), 20% Sweet Bran, and 2.5% supp...

This paper presents a high-quality and area-efficient ramp generator to be used for on-chip testing of analog and mixed-signal circuits. An original adaptive scheme is developed to palliate the inaccuracy of a basic ramp generator. As a result, the proposed adaptive ramp generator exhibits very good performances in terms of slope precision and ramp linearity while maintaining a low area overhead.

PURPOSE Guidelines suggest that individualized ramp protocols with treadmill times targeted between 8 and 12 minutes are most suitable to estimate exercise capacity. However, previous methods to determine individualized ramp rates and comparisons between ramp and standardized protocols have been limited to clinically referred populations. METHODS Forty-three healthy volunteers [median (interq...

Abstract Several brachiopod-rich mud mounds occur in the upper Visean (Brigantian) of Derbyshire Carbonate Platform succession UK. The re-evaluation lithofacies architecture a mound complex, developed an intraplatform middle-ramp environment, led to recognition three associations: (a) 10 m thick basal unit automicrite boundstone with siliceous sponge spicules and brachiopod–bryozoan packstone w...

Thresholds for detection and discrimination of the polarity (phase) of repetitive gratings with a ramp luminance profile were compared to sine-wave thresholds in normal and amblyopic observers. In the high-frequency range (4 cy/deg), normal observers detected ramp-wave gratings when the contrast of the fundamental spatial frequency was close to its independent threshold and discriminated the po...

Rapid confirmation of herpes simplex virus (HSV) is essential in many clinical settings. Viral isolation in cell culture is the standard method for diagnosing HSV infection, with confirmation by specific immunological staining. The performance of the Rapid Absorbent Matrix Pad (RAMP) HSV culture confirmation test was evaluated with specimens obtained from 71 patients with suspected HSV infectio...

Repetitive, brief target ramp movements every few seconds lead to anticipatory acceleration before each ramp onset and anticipatory deceleration before ramp offset. We assessed whether identifying novel changes in the pursuit target would alter this pattern of anticipatory pursuit. Without target identification (TI), anticipatory acceleration increased when intervals between ramps were regular,...