The title compound, C(25)H(23)NO, consists of a biphenyl-4-carbonyl unit attached to an exocyclic double bond group at position 2 of an indole unit, which presents methyl groups as substituents at positions 1 and 3. The mol-ecular conformation is s-cis with an E configuration, supported by weak intra-molecular C-H⋯O contacts involving the methyl groups and the carbonyl function. The rings of th...

The title compound, C20H26O6, is chiral and crystallizes as a racemate: the relative configuration of the stereogenic centres is 1R*,2R*,3S*,4R*. The cyclo-hexane ring has a chair conformation. The ethyl fragment of the eth-oxy-carbonyl group in the 3-position is disordered over two sets of sites in a 0.650 (6):0.350 (6) ratio. The hy-droxy group acts as a bifurcated hydrogen-bond donor, formin...

THE CRYSTAL STRUCTURE OF THE TITLE COMPOUND [SYSTEMATIC NAME: (2R)-3-(1H-indol-3-yl)-2-(4-nitro-1,3-dioxoisoindolin-2-yl)propanoic acid], C(19)H(13)N(3)O(6), an analogue of epigenetic modulator RG108, is constrained by strong hydrogen bonds between the indole N-H group and a carbonyl O atom of the phthalimide ring of a symmetry-related mol-ecule, and between the protonated O atom of the carboxy...

Carbamoyl anions, generated from N,N-disubstituted formamides and lithium diisopropylamide, add with high diastereoselectivity to chiral N-sulfinyl aldimines and ketimines to provide α-amino amides. The methodology enables the direct introduction of a carbonyl group without the requirement of unmasking steps as with other nucleophiles. The products may be converted to α-amino esters or 1,2-diam...

In the title mol-ecule, C(23)H(18)O(3), the dihedral angle between the two naphthalene ring systems is 80.44 (4)°. The mean plane of the bridging carbonyl C-C(=O)-C group makes a torsion angle of -68.55 (17)° with the naphthalene system of the 2,7-dimeth-oxy-naphthalene unit and a torsion angle of -9.01 (19)° with the naphthalene ring system of the naphthoyl group. In the crystal, a weak C-H⋯O ...

Microbial transformations of racemic 7-hydroxyflavanone using strains of genus Aspergillus (A. niger KB, A. niger 13/5, A. ochraceus 456) and the species Penicillium chermesinum 113 were studied. The products of O-methylation, O-methylation along with hydroxylation at C-3' and C-4', reduction of the carbonyl group, reduction of the carbonyl group along with hydroxylation at C-5, and dehydrogena...

elloramycin seriesio~13) form a discrete group of metabolites related by molecular structure and biological activity, particularly against Grampositive bacteria of the genus Streptomyces. Characteristic of the group is a linear tetracyclic ring system carrying methyl, carbonyl, carboxyl, and hydroxyl functions which may be methylated or glycosylated. The DC-rings of the systems knownto date are...

In the title compound, C(15)H(10)Cl(3)NO(2), an intra-molecular N-H⋯O hydrogen bond forms a six-membered ring and enforces an almost coplanar conformation for the acetamido group, the central benzene ring and the bridging carbonyl C-C(=O)-C group: the dihedral angles between the benzene ring and the acetamide and carbonyl C-C(=O)-C planes are 7.06 (11) and 7.17 (12)°, respectively. The dihedral...

In the title compound, C(16)H(15)NO, the two aromatic rings are approximately perpendicular; the carbonyl group is twisted out of the adjacent benzene ring by 14.8 (2)°. In the heterocyclic ring, the C atom linked to the carbonyl group and the C atom linked to the N atom have opposite deviations of 0.467 (5) and 0.184 (4) Å, respectively, from the plane of the benzene ring. The N atom lies appr...

The oxazine ring in the title compound, C(21)H(14)N(2)O(5), adopts a flattened boat conformation. The nitro-phenyl ring and the naphthalene ring system enclose a dihedral angle of 89.2 (1)°. An intra-molecular hydrogen bond is formed between the NH group and one of the adjacent carbonyl O atoms. In addition, the NH group forms an inter-molecular hydrogen bond to a symmetry equivalent of this ca...