BACKGROUND Cellulose acetate phthalate (CAP) in soluble form blocks coreceptor binding sites on the virus envelope glycoprotein gp120 and elicits gp41 six-helix bundle formation, processes involved in virus inactivation. CAP is not soluble at pH < 5.5, normal for microbicide target sites. Therefore, the interaction between insoluble micronized CAP and HIV-1 was studied. Carbomer 974P/BufferGel;...

Carbomers are carboxyvinylic derivatives that are widely used in the manufacture of hydrogel dosage forms. Because of their anionic nature and large number of acid groups, they tend to interact with cationic substances, and with other hydrophilic polymers containing alcohol groups. Here, we report a study of interactions between the carbomer Carbopol and the cationic drug propranolol hydrochlor...

the purpose of this study was to design and optimize an oral controlled release acyclovir mucoadhesive tablet, in term of its drug release and mucoadhesive strength. a 32 full factorial design was employed to study the effect of independent variables like carbopol-934p and hydroxypropyl methylcellulose k100m, which significantly influence characteristics like swelling index, ex-vivo mucoadhesiv...

Furosemide is a sulfonamide-derived diuretic drug which an alternative treatment for heart failure. was made into slow-release tablets to improve the criteria poor furosemide and maximize its absorption in stomach. The purpose of this study determine whether floating with concentration 23% carbopol matrix could meet requirements evaluating physical properties compared theoretically literatur. r...

In this study, the effects of various hydrophilic (HPMC and Carbopol 971) and plastic (Ethylcellulose and Eudragit RL100) polymers on the release profile of diltiazem HCl from matrix tablets were evaluated in-vitro. For this purpose, tablets containing 60 mg of diltiazem HCl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. Tablets prep...

Latar belakang: Salep yang mengandung ekstrak ikan gabus dan madu kelulut terbukti mendukung penyembuhan luka. Sediaan salep pada penelitian sebelumnya menyatakan bahwa adanya ketidakstabilan sediaan. Hal ini ditandai dengan terjadinya pemisahan fase, ditambahkan carbopol untuk mencegah pemisahan. Tujuan berguna memperlihatkan sifat fisik ketika sebagai peningkat kosistensi sediaan terhadap sal...

In this work, the effect of cellulosic polymer and chemical structure of salicylic acid and its various esters on their release has been analysed. The release of different drugs in distinct types of vehicles, cetyl excipient, polyethylene glycol and Carbopol gel was also studied.  2001 Published by Elsevier Science B.V.