Depressive-like behavior is a highly prevalent worldwide neuropsychiatric disorder that owns complex pathophysiologic mechanism. The available pharmacotherapy ineffective for most patients and shown several adverse effects. Therefore, it important to find efficacy safe antidepressive compounds. Some phytochemicals compounds regulate the same genes pathways targeted by drugs; therefore, diets ri...

The aim of this study was to test the hypothesis that depression and anxiety are associated with electrocardiographic (ECG) repolarization abnormalities in the Multi-Ethnic Study of Atherosclerosis (MESA), a cohort free of symptomatic cardiovascular disease. Depressive symptoms were assessed by using the Center for Epidemiologic Studies Depression Scale and trait anxiety symptoms by using the S...

INTRODUCTION The role of the menopausal transition and associated menopausal symptoms in the occurrence of depressive disorders has been discussed and debated for a long time. Most previous clinical studies had limited case samples, and did not control the attributable risk of medical comorbidities. METHODS Patients with a diagnosis of symptomatic menopausal transition and without a psychiatr...

Patients with bipolar disorder are at very high risk for suicidal ideation, non-fatal suicidal behaviors and suicide and are frequently treated with antidepressants. However, no prospective, randomized, controlled study specifically evaluating an antidepressant on suicidality in bipolar disorder has yet been completed. Indeed, antidepressants have not yet been shown to reduce suicide attempts o...

The core issue regarding antidepressants for many clinicians is whether they perform significantly better than placebos. However, this article suggests eight additional concerns beyond drug efficacy alone to consider regarding antidepressants including: (1) formulating only a one-dimensional, biological view of depression; (2) defining the client's role as passive in treatment; (3) economic cor...

OBJECTIVE To enable multicriteria benefit-risk (BR) assessment of any number of alternative treatments using all available evidence from a network of clinical trials. STUDY DESIGN AND SETTING We design a general method for multicriteria decision aiding with criteria measurements from Mixed Treatment Comparison (MTC) analyses. To evaluate the method, we apply it to BR assessment of four second...

BACKGROUND Increased prescription of antidepressants has been consistently associated with a decrease in suicide rates in several countries. The aim of this study is to explore antidepressant consumption, suicide rates and admission for depression in the Veneto Region, Italy, in order to see whether the same pattern could be detected. METHODS Data from the Italian Ministry of Health (admissio...

The combined data was obtained from two pilot, phase 2, parallel design, single-center clinical studies in which a novel antidepressant was used to treat a population with major depression. Inpatients (N=52) were enrolled in the first study [1] and outpatient (N=55) – in the second study [2]. Both studies investigated the efficacy and safety of the new drug for one or two 5-day treatment cycles...

Sir: In re-evaluating lithium augmentation studies Joanna Moncrieff (1997) quotes our study, but appears not to have read it. She writes “¿ The largest and longest of them [lithium augmentation studies], which followed up 34 patients for three weeks, was negative (Stein & Barnadt, 1988)―,whereas we actually reported on 24 patients followed up for nine weeks and that there were significant l...