OBJECTIVES The purpose of this study was to explore a novel disease gene for hypertrophic cardiomyopathy (HCM) and to evaluate functional alterations caused by mutations. BACKGROUND Mutations in genes encoding myofilaments or Z-disc proteins of the cardiac sarcomere cause HCM, but the disease-causing mutations can be found in one-half of the patients, indicating that novel HCM-susceptibility ...

A field isolate of pike fry rhabdovirus (PFR-80560) isolated from roach was tested for pathogenicity in fry of roach Rutilus rutilus L., common carp Cyprinus carpio L., grass carp Ctenopharyngodon idella Valenciennes and rainbow trout Oncorhynchus mykiss Richardson. The fish were experimentally exposed to the virus by immersion in a virus-seeded water-bath. We also compared the pathogenicity of...

Stearoyl-CoA desaturases (SCDs) are key enzymes of fatty acid biosynthesis whose regulation underpins responses to dietary, thermal, and hormonal treatment. Although two isoforms are known to exist in the common carp and human and four in mouse, there is no coherent view on how this gene family evolved to generate functionally diverse members. Here we identify numerous new SCD homologs in teleo...

MicroRNAs (miRNAs) are small non-coding RNA molecules that are processed from large 'hairpin' precursors and function as post-transcriptional regulators of target genes. Although many individual miRNAs have recently been extensively studied, there has been very little research on miRNA transcriptomes in teleost fishes. By using high throughput sequencing technology, we have identified 167 and 1...

INTRODUCTION The presence of a new autoantibody system, anti-carbamylated protein (anti-CarP) antibodies, has been identified in rheumatoid arthritis (RA). The presence of anti-CarP antibodies was evaluated in samples taken from individuals who subsequently developed RA before and after onset of symptoms and related to previously analysed antibodies against citrullinated peptides (ACPA specific...

In this chapter, a new dynamic capacitated arc routing problem (CARP) is defined and investigated. Compared with the static CARP and other dynamic CARP investigated by the existing researches, the new dynamic CARP is more general and closer to reality, and thus is more worthwhile to be solved. Due to the stochastic factors included in the dynamic CARP, the objective is not to obtain the optimal...

BACKGROUND Common carp (Cyprinus carpio) is one of the most important aquaculture species of Cyprinidae with an annual global production of 3.4 million tons, accounting for nearly 14% of the freshwater aquaculture production in the world. Due to the economical and ecological importance of common carp, genomic data are eagerly needed for genetic improvement purpose. However, there is still no su...

BACKGROUND Confluent and reticulated papillomatosis (CARP), also known as Gougerot-Carteaud syndrome, is a rare disorder. It usually presents as hyperkeratotic brown papules that coalesce into plaques with a reticulated periphery on the central trunk of young adults. Confluent and reticulated papillomatosis is most often clinically confused with tinea versicolor and usually does not respond to ...

In this study adsorption of Cd onto TiO2 nanoparticles and natural sediment particles (SP) were studied and the facilitated transports of Cd into carp by TiO2 nanoparticles and SP were assessed by bioaccumulation tests exposing carp (Cyprinus carpio) to Cd contaminated water in the presence of TiO2 and SP respectively. The results show that TiO2 nanoparticles had a significantly stronger adsorp...

The activity of 5-aminolevulinic acid dehydratase (ALA-D) in the blood of crucian carp, Carassius auratus langsdorfiii, was measured under a variety of lead exposure conditions. A three-week exposure of crucian carp to water lead concentrations of 3, 10, and 30 ppb inhibited their ALA-D activities with increasing water lead concentrations. When crucian carp were exposed to a water lead concentr...