One hundred eighty-eight male calves were randomly assigned to one of five treatments at about 6 wk of age t o determine the effect of castration at different weights on feedlot performance and carcass characteristics. Calves were castrated at 70, 230. 320 or 410 kg or left intact. All calves received a 36-mg zeranol implant 6 0 d postweaning and were re-implanted every 56 d for the duration of...

The involution of the rat ventral prostate gland after castration could be caused by primary changes in the vasculature. To explore the mechanisms, we studied the effects of castration and testosterone treatment on the vasculature in the ventral prostate in adult rats and mice. Androgen receptor expression, vascular morphology, and the expression of angiopoietin (ang) 1 and 2 and their receptor...

We previously established the autochthonous transgenic adenocarcinoma mouse prostate (TRAMP) model to facilitate characterization of molecular mechanisms involved in the initiation and progression of prostate cancer. TRAMP mice display high grade prostatic intraepithelial neoplasia or well-differentiated prostate cancer by 10-12 weeks of age. To test the hypothesis that molecular events leading...

Young male albino rats yawn significantly more than females or castrated males when injected with physostigmine (0.10 mg/kg). Treatment with testosterone (100 micrograms daily) during seven days restores cholinomimetically induced yawning in castrated males, and increases yawning in normal and androgenized females. Treatment with estradiol (200 micrograms daily) during one week does not modify ...

Lower urinary tract symptoms secondary to posterior urethral valves (PUV) arise in boys during adolescence. The reasons for this have previously been attributed to increased urine output as boys experience increased growth. Additionally, there are few choices for clinicians to effectively treat these complications. We formed the new hypothesis that increased androgen levels at this time of chil...

Objective: This study aims to determine the intake, digestibility of nutriens and growth performance Kacang goats that were given complete feed in terms sex differences, castration treatment. Methods: The research took place experimental enclosure faculty Agriculture, Timor University from Marh October 2021. livestock used 15 young goats, which divided into 3 treatment groups. three groups T1 (...

Because of its anabolic effects on muscle, testosterone is being explored as a function-promoting anabolic therapy for functional limitations associated with aging; however, concerns about testosterone's adverse effects on prostate have inspired efforts to develop strategies that selectively increase muscle mass while sparing the prostate. Testosterone's promyogenic effects are mediated through...

Although antiandrogen therapy has been shown effective in treating prostatic tumors, it is relatively ineffective in treating benign prostatic hyperplasia (BPH). In an attempt to understand better the role of androgens in the development of the normal prostate and BPH, we studied the relative effects of testosterone and IGF-I on the development of the two compartments of the prostate in castrat...

The present study aimed to evaluate the effects of immunocastration on animal growth, carcass traits, and meat quality Nellore cattle receiving or not Ionophore supplementation at pasture with concentrate (semi-feedlot). first experiment (Pasture) was carried out during rainy season, while second (supplemented = Semi-feedlot) conducted dry season. In each assessment, 60 males were allocated int...

The influence of testosterone on gonadotropin-releasing hormone (GnRH) secretion was assessed indirectly by altering the serum testosterone concentration of male rats and measuring GnRH release from their incubated hypothalami 1 wk later.GnRH release from hypothalami of castrated rats was 13.4+/-1.2 (SE) pg/h, compared to 35.3+/-3.8 pg/h from hypothalami of intact rats (P < 0.001). GnRH release...