leiomyomatosis peritonealis disseminata is a very rare condition characterized by the development of multiple smooth muscle-like nodules in the peritoneal cavity. it is associated with increased serum levels of gonadal steroids. the present report describes a 29-year-old patient underwent transabdominal hysterectomy and bilateral salpingo oophorectomy six years ago because of leiomyomatosis per...

Ameliorative effect of citrus peel extract on castration-induced oxidative stress in liver and kidney ratsNada A. E. Mohamed, Amany Tohamy, Basma Elgamal Ahmed Abdel moneim

Castration can change levels of plasma testosterone. Androgens such as testosterone play an important role in stabilizing birdsong. The robust nucleus of the arcopallium (RA) is an important premotor nucleus critical for singing. In this study, we investigated the effect of castration on singing patterns and electrophysiological properties of projection neurons (PNs) in the RA of adult male zeb...

OBJECTIVE To review and evaluate current literature on the US Food and Drug Administration (FDA)-approved drug enzalutamide (XTANDI(®)) in metastatic castration-resistant prostate cancer. DATA SOURCES Literature search was done through PubMed using the terms enzalutamide, MDV3100, abiraterone, and castration-resistant prostate cancer. Data from FDA product labels were also used. STUDY SELEC...

INTRODUCTION One fifth of men with newly diagnosed prostate cancer present with locally advanced or metastatic disease. Androgen deprivation therapy (ADT) is the standard systemic therapy in these patients. Despite initial response, essentially all patients will develop castration resistant prostate cancer (CRPC). In this review, we will discuss the revised definitions of CRPC and the latest un...

Prostate growth and physiology are regulated by steroid hormones and modulated by multiple endocrine factors. We investigated the action of insulin on the tissue organization and kinetics of epithelial cells in the rat ventral prostate (VP) in response to castration up to 120 hours after surgery by using an acute protocol of alloxan-induced diabetes. Diabetes caused a reduction in volume densit...

Adult male Eastern Fence Lizards (Sceloporus undulatus) possess blue and black ventral patches that function in sex recognition and intrasexual social signaling, but this ventral coloration is absent or greatly reduced in females and juvenile males. Adult males also exhibit a relatively uniform, reddish brown dorsal coloration, while females and juvenile males are cryptically colored, with two ...

Androgen receptor (AR) splice variants lacking the ligand binding domain (ARVs), originally isolated from prostate cancer cell lines derived from a single patient, are detected in normal and malignant human prostate tissue, with the highest levels observed in late stage, castration-resistant prostate cancer. The most studied variant (called AR-V7 or AR3) activates AR reporter genes in the absen...

Prostate cancer is the most commonly diagnosed malignancy in men. While tumors initially respond to androgen-deprivation therapy, the standard care for advanced or metastatic disease, tumors eventually recur as castration-resistant prostate cancer (CRPC). Upregulation of the insulin-like growth factor receptor type I (IGF-IR) signaling axis drives growth and progression of prostate cancer by pr...