A fall in blood pH was generated either by infusion of HCl or by reducing gill ventilation and raising blood PCO2 in rainbow trout, Salmo gairdneri Richardson. The acute acidosis resulting from HCl infusion caused an increase in plasma adrenaline and noradrenaline concentrations, the adrenaline increase being proportional to the decrease in blood pH. Fish subjected to a prolonged respiratory ac...

Pheochromocytoma/paraganglioma (PPGL) are neuroendocrine tumors that frequently produce and release catecholamines. Catecholamine excess can manifest in several cardiovascular syndromes, including cardiomyopathy. PPGL-induced cardiomyopathies occur up to 11% of cases most often associated with an adrenal pheochromocytoma (90%) rarely a paraganglioma derived from the sympathetic ganglia (10%). P...

1. The clinical utility of plasma metadrenalines for examination of sympatho-adrenal function and catecholamine metabolism was assessed from plasma measurements of these metabolites in a number of clinical conditions (hypertension, cardiac failure, bilateral adrenalectomy and X-chromosomal deletions of the gene for monoamine oxidase), and before and during activation of sympathetic outflow or i...

Methylation of 2-hydroxyestradiol to 2-methoxyestradiol by catechol-O-methyl transferase (COMT) mediates the antimitogenic effects of 2-hydroxyestradiol on vascular smooth muscle cells. Moreover, 2-hydroxyestradiol inhibits growth of glomerular mesangial cells (GMCs). Because catecholamines are substrates for COMT, which is expressed in GMCs, we hypothesize that catecholamines may abrogate the ...

BACKGROUND Takotsubo cardiomyopathy (TCM) is characterized by regional left ventricular dysfunction that cannot be explained by an occlusive lesion in a coronary artery. Catecholamines are implicated in the pathogenesis of TCM but the mechanisms involved are unknown. Because the endogenous and the most commonly used exogenous catecholamines have well defined adrenoceptor subtype affinities, inf...

ACTH “big ACTH”, 175 “little ACTH”, 175 Acetyl strophanthidin, radioimmunoassay, 221 Adenylate cyclase activity, measurement by radioimmunoas8ay, 312 beta-Adrenergic binding sites catecholamine assay vehicle, 259 heart muscle membrane fractions, 259 Adrenergic receptors, current concepts, 259 alpha-Adrenergic receptors, catecholamines, 261 beta-Adrenergic receptors, catecholamines, 261 Aldoster...

A. Distribution of catecholamines in the hypothalamus and effect of norepinephrine on the paraventricular nucleus 1603 B. Hypothalamic catecholamines and normal blood pressure 1603 C. Hypothalamic catecholamines and hypertension 1604 D. Summary 1604 E. Effect on hypothalamic noradrenergic activity of an increase in sodium intake in the young SHR 1604 F. Evidence for an increase in norepinephrin...

It is well known that catecholamines significantly modify the sympathetic ganglionic transmission (1-10). Since Eccles and Libet (7) proposed a model of ganglionic transmis sion characterized by adrenergically mediated hyperpolarizing potentials, many reports have appeared concerning the action and the physiologic role of catecholamines in sympa thetic ganglia. De Groat and Volle (9) have inves...

In isolated ventricles of old (9-19 day) chick embryonic hearts made inexcitable by inactivating the fast sodium channels with either tetrodotoxin (TTX) or elevated external potassium, catecholamines induced slow electrical responses and concomitant contractions within 1-3 minutes. These slow responses had a higher threshold and propagated at a slower velocity than did the normal action potenti...

It has been suggested that β2-adrenergic receptor (β2-AR)-mediated signaling induced by catecholamines regulates the degradation of p53. However, the underlying molecular mechanisms were not known. In the present study, we demonstrated that catecholamines upregulated the expression of silent information regulator 1 (Sirt1) through activating β2-AR-mediated signaling pathway, since selective β2-...