In this work, we are interested in finding new catalysts for catecholase, whose principle is based on the oxidation reaction of catechol to o-quinone. We approached synthesis threes tripod ligands pyrazole a condensation and its characterization by IR, 13C NMR, 1H NMR spectroscopy, then evaluated catalytic properties certain complexes formed situ catalyze catechols o-quinones. The aim find righ...

The adhesive system of mussels evolved into a powerful and adaptive system with affinity to a wide range of surfaces. It is widely known that thereby 3,4-dihydroxyphenylalanine (Dopa) plays a central role. However underlying binding energies remain unknown at the single molecular scale. Here, we use single-molecule force spectroscopy to estimate binding energies of single catechols with a large...

Joseph R. Mazzulli,1 Amanda J. Mishizen,1,3 Benoit I. Giasson,2 David R. Lynch,1,3 Steven A. Thomas,2 Akira Nakashima,4 Toshiharu Nagatsu,5 Akira Ota,4 and Harry Ischiropoulos1,2,3 1The Joseph Stokes Jr. Research Institute and Departments of 2Pharmacology and 3Pediatrics, The Children’s Hospital of Philadelphia and The University of Pennsylvania, Philadelphia, Pennsylvania 19104, and Department...

A series of vanadium(V) complexes with o-dioxolene (catecholato) ligands and an ancillary ligand, (N-(salicylideneaminato)ethylenediamine) (hensal), were investigated using 51V solid-state magic angle spinning NMR spectroscopy (51V MAS NMR) to assess the local environment of the vanadium(V). The solid-state 51V NMR parameters of vanadium(V) complexes with a related potentially tetradentate anci...

We assessed the sensitivity and specificity of glucagon stimulation and clonidine suppression tests in the diagnosis of pheochromocytoma in 113 hypertensive patients, 39 with and 74 without the tumor. In the glucagon stimulation test, blood was sampled 2 minutes after intravenous injection of 0.28 mumol (1 mg) glucagon, and in the clonidine suppression test, blood was sampled 3 hours after admi...

BACKGROUND Smoking has been hypothesized to decrease biosynthesis of parent estrogens (estradiol and estrone) and increase their metabolism by 2-hydroxylation. However, comprehensive studies of smoking and estrogen metabolism by 2-, 4-, or 16-hydroxylation are sparse. METHODS Fifteen urinary estrogens and estrogen metabolites (jointly called EM) were measured by liquid chromatography/tandem m...