The kinetics of changes in inflammatory indices in induced sputum from eight prednisone dependent asthmatics whose minimum clinical maintenance and exacerbation doses were known were investigated. The study began on the last day of a course of 30 mg prednisone daily for one week. Thereafter, the daily prednisone was reduced in a structured way to below the maintenance dose. This treatment was c...

The purpose of this study was to develop a ternary complex of plasmid DNA (pDNA) electrostatically assembled with polyamidoamine (PAMAM) dendrimer and chondroitin sulfate (CS) for effective and secure gene delivery. PAMAM dendrimers are new cationic polymers that are expected to be used as gene delivery vectors. However, cationic non-viral gene vectors showed cytotoxicity by binding to negative...

Optimization of a serotype-selective, small-molecule inhibitor of botulinum neurotoxin serotype A (BoNTA) endopeptidase is a formidable challenge because the enzyme-substrate interface is unusually large and the endopeptidase itself is a large, zincbinding protein with a complex fold that is difficult to simulate computationally. We conducted multiple molecular dynamics simulations of the endop...

We report on the exploitation of a new tetrazole-substituted 1,10-phenanthroline and a 2,2'-bipyridine (bpy) ancillary ligand modified with an electron-donating group in cationic ruthenium complexes. This complex, placed in between two electrodes without any polymer, demonstrates high efficiency near-infrared (NIR) electroluminescence (EL). The comparison between bpy and its methyl-substituted ...

Water-soluble, cationic conjugated polymer binds single-stranded DNA with higher affinity than it binds double-stranded or otherwise "folded" DNA. This stronger binding results from the greater hydrophobicity of single-stranded DNA. Upon reducing the strength of the hydrophobic interactions, the electrostatic attraction becomes the important interaction that regulates the binding between the wa...

Reaction of mercuric acetate with an imidazolium-linked cyclophane incorporating 2,6-phenolic moieties results in formation of an interesting new N-heterocyclic carbene (NHC) complex of mercury. The new complex is cationic and binuclear, incorporating two mercury centres and two bis(NHC) ligands, each mercury atom being bound by two NHC moieties and two phenol/phenoxy moieties. Forms of the com...

The asymmetric unit of the title compound, [RhCl(2)(C(10)H(8)N(2))(2)]ClO(4), consists of one unit of the cationic complex [RhCl(2)(bipy)(2)](+) and one uncoordinated perchlorate anion. The Rh(III) atom is coordinated by four N atoms from two bipyridyl ligands and two Cl atoms, forming a distorted octa-hedral environment. The Cl ligands are cis. Two intramolecular C-H⋯Cl hydrogen bonds occur in...

The reaction of [Ru(L)2(H2biim)](ClO4)2 [L1 = 2,2¢-bipyridine (bpy) or L2 =  2-(phenylazo)pyridine (pap) and H2biim = 2,2¢-biimidazole] with Au(tht)Cl (tht = tetrahydrothiophene) in presence of base in methanol produced a terametallic cationic complex [{Ru(L)2(biim)}<s...

A cationic mononitrosyl dinuclear ruthenium complex was prepared by removing one NO ligand of a dicationic dinitrosyl ruthenium complex using NaN3. Reduction and oxidation reactions of the mononitrosyl complex led to the isolation of a neutral nitrosyl-bridged complex and a dicationic mononitrosyl complex, respectively, as expected from the cyclic voltammogram. According to the electron count, ...

Luminescent metal complexes are a valuable platform for the generation of cell imaging agents. However, many cationic, factor that can dominate intracellular accumulation to specific organelles. Neutral Re(I) offer more attractive development bioconjugated agents, where charge cannot influence their distribution. Herein, we report synthesis neutral complex (ReAlkyne), which was used as four car...