UNLABELLED Cholangiocarcinoma (CCA) is an often fatal primary malignancy of the intra- and extrahepatic biliary tract that is commonly associated with chronic cholestasis and significantly elevated levels of primary and conjugated bile acids (CBAs), which are correlated with bile duct obstruction (BDO). BDO has also recently been shown to promote CCA progression. However, whereas there is incre...

Human perception of music and image are highly correlated. Both of them can inspire human sensation like emotion, power etc. This paper preliminarily investigates how to model the relationship between music and image using 47,888 music-image pairs extracted from music videos. We have two basic observations for this relationship: 1) music space exhibits simpler cluster structure than image space...

Many cyanobacteria are able to alter the pigment composition of the phycobilisome in a process called complementary chromatic adaptation (CCA). The regulatory mechanisms of CCA have been identified in Fremyella diplosiphon, which regulates both phycoerythrin and phycocyanin levels, and Nostoc punctiforme, which regulates only phycoerythrin production. Recent studies show that these species use ...

BACKGROUND/AIMS To evaluate the expression of CXC motif chemokine receptor 4 (CXCR4) in the tissues of patients with hilar cholangiocarcinoma (hilar-CCA) and to investigate the cell proliferation and frequency of neural invasion (NI) influenced by RNAi-mediated CXCR4 silencing. METHODS An immunohistochemical technique was used to detect the expression of CXCR4 in 41 clinical tissues, includin...

In this paper we report on the investigation, description and analysis of communication and co-ordination practices in software engineering projects. We argue that existing models of the software process do not adequately address the situated, day-to-day practices in which software engineers collectively engage, yet it is through these practices that effective co-ordination is achieved. Drawing...

Zinc-fingers and homeoboxes 1 (ZHX1) is a transcription repressor that has been associated with the progressions of hepatocellular carcinoma, gastric cancer, and breast cancer. However, the functional roles of ZHX1 in cholangiocarcinoma (CCA) have not been determined. We investigated the expression and roles of ZHX1 during the proliferation, migration, and invasion of CCA cells. In silico analy...

Ranking relevance degree information is widely utilized in the ranking models of information retrieval applications, such as text and multimedia retrieval, question answering, and visual search reranking. However, existing feature dimensionality reduction methods neglect this kind of valuable potential supervised information. In this paper, we extend the pairwise constraints from the traditiona...

the effect of environmental factors on plant vegetation is different. therefore, it is necessary to evaluate role of these factors in medicinal plants growth, development and essential oil. this study was performed to investigate the effect of factors on qualitative and quantitative variations of the essential oil of verbascum songaricum in its habitats in central zagros mountains, iran in 2012...

BACKGROUND Cholangiocarcinoma (CCA) is the second most common primary liver cancer, being characterized by its late diagnosis and fatal outcome. Recent epidemiological reports indicate an increasing worldwide incidence of intrahepatic CCA but a decreasing incidence of extrahepatic CCA. METHODS In this review, we present an overview of the incidence and epidemiology of CCA and possible strateg...

Cholangiocarcinoma (CCA) is a devastating disease due to resistance to traditional chemotherapies and radiotherapies. New therapeutic strategies against CCA are urgently needed. This study investigated the role of lipocalin-2 (LCN2) in human cholangiocarcinoma as a potential therapeutic target and diagnostic marker. So far, the role of LCN2 in cancer is still controversial and studies regarding...