Liver injury can be acute or chronic, resulting from a variety of factors, including viral hepatitis, drug overdose, idiosyncratic reaction, toxins, while the progression pathogenesis in liver rises due to involvement numerous cytokines and growth factor mediators. Thus, identification more effective biomarker-based active phytochemicals isolated medicinal plants is promising strategy protect a...

This study aimed to in vivo evaluate the effect of Plantago lanceolata aqueous extract on kidney function test ( total serum protein, urea and creatinine) anti-inflammatory through determined day require heal burn mice skin.. is a species flowering plant Plantaginaceae (plantain) family, seems be very versatile addition medicine cabinet being an antifungal, antioxidant, analgesic many other med...

This work was done to evaluate the effect of ethanolic extract Palisota hirsuta on nephrotoxicity induced by carbontetrachloride (CCl4). Biochemical analyses were carried out determine levels creatinine, urea, total protein, chloride, carbonate using assay kits (products Randox Laboratories Crumlin and Teco Diagnostics), sodium, potassium (method Tietz,) malondialdelyde (MDA) level (thiobarbitu...

INTRODUCTION CCN4, also termed WNT-inducible signaling pathway protein-1 (WISP-1), has important roles in inflammation and tissue injury. This study aimed to investigate the effect of CCN4 inhibition using monoclonal anti-CCN4 antibody (CCN4mAb) on the liver injury and fibrosis in a mouse model of liver fibrosis. MATERIAL AND METHODS The mouse liver fibrosis model was induced by carbon tetrac...

PURPOSE Retinal pigment epithelial (RPE) cells have an important role in the immune suppression associated with the immune privilege of the eye. Some aspects of this remain unclear and this study aimed to determine how RPE cells could influence the production of chemokines by T lymphocytes. METHODS T lymphocytes, separated from peripheral blood of normal volunteers, and RPE cells, cultured fr...

BACKGROUND Ginseng essence (GE) is a formulation comprising four medicinal and edible herbs including ginseng (Panax ginseng), American ginseng (Panax quinquefolius), lotus seed (Nelumbo nucifera), and lily bulb (Lilium longiflorum). This study was aimed at investigating the hepatoprotective effect of GE against carbon tetrachloride (CCl4)-induced liver injury in rats. METHODS We treated Wist...

The aim of this study is to investigate the effect of alcoholic and aqueous extracts of Nigella sativa seeds on the reproductive values, some sexual hormones level and histological change of treated and normal male mice at one spermatogenesis cycle (five weeks). Sixty albino Swiss male mice were used as animal model, they divided into six groups equally, and 1st group served as control group, t...

CCl4-induced liver damage was modeled in monolayer cultures of rat primary hepatocytes with a focus on involvement of covalent binding of CCl4 metabolites to cell components and/or peroxidative damage as the cause of injury. (1) Covalent binding of 14C-labeled metabolites was detected in hepatocytes immediately after exposure to CCl4. (2) Low oxygen partial pressure increased the reductive meta...

The effect of pentoxifylline (PTX) on acute liver injury caused by CCl4 or acetaminophen was studied in the rat. PTX was given twice daily (18, 36 or 72 mg/kg), intraperitoneally (ip) for 5 days prior to CCl4 or acetaminophen. In addition, the effect of PTX administered simultaneously with CCl4 or acetaminophen was evaluated. Rats were killed 72 h or 48 h after CCl4 or acetaminophen administrat...

Few data are available in the literature regarding the effect of pentosan polysulfate (PPS) on normal and fibrotic rat livers. In addition, the combination of PPS and carbon tetrachloride (CCl4) has not been studied so far. The objective of this study was to assess the effect of PPS on rat livers treated or not with CCl4 for the induction of liver fibrosis. The study consisted of four stages: 1...