نتایج جستجو برای: ccnu
تعداد نتایج: 395 فیلتر نتایج به سال:
-Experiments have been carried out to determine whether the growth delay induced in small EMT6 spheroids (-250 ,um in diameter) by a range of cytotoxic drugs can be increased by pre-incubation of the spheroids under hypoxic conditions with misonidazole (MISO). Hypoxic pre-incubation was for 3 or 5 h in the presence of 5 mm MISO, and caused a growth delay of about 1 day or 2 days respectively. S...
' Aided by Research Grant CA-11811 from the NIH and by research funds from the United States Veterans Administration. 2 The abbreviations used are: c/s-Ptll, cw-dichlorodiammineplatinum(H) (NSC 119875); c/s-PPC, m-dichloro(dipyridine)platinum (II); EATC, Ehrlich ascites tumor cells; TCA, trichloroacetic acid; HN2, nitrogen mustard; DMSO, dimethyl sulfoxide; MEM, Eagle's minimum essential medium...
Summary We develop DiffGraph, anRpackage that integrates four influential differential graphical models for identifying gene network rewiring under two different conditions from gene expression data. The input and output of different models are packaged in the same format, making it convenient for users to comparedifferent models using a wide range of datasets and carry out follow-up analysis. ...
BACKGROUND We previously developed a mathematical model capturing tumor size dynamics of adult low-grade gliomas (LGGs) before and after treatment either with PCV (Procarbazine, CCNU, and Vincristine) chemotherapy alone or with radiotherapy (RT) alone. OBJECTIVE The aim of the present study was to present how the model could be used as a simulation tool to suggest more effective therapeutic s...
Previous studies with temozolomide suggest that a prolonged duration of chemotherapy is important for treating low-grade gliomas (LGGs). PCV (procarbazine, CCNU, vincristine) chemotherapy has demonstrated efficacy in treating LGGs, but this therapy cannot be used for a prolonged period because of the cumulative toxicity. The aim of the present study was to evaluate the impact of first-line PCV ...
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