Chiral separation of deprenyl-N-oxide isomers is presented using capillary electrophoresis in the presence of various cyclodextrin (CD) derivatives. This recently identified metabolite of R-(-)-deprenyl may possess desirable pharmacological activities. The effect of the cavity size and the substituents of the CD are examined on the enantiomer resolution of the compound having an asymmetric cent...

INTRODUCTION Soluble forms of tumor necrosis factor (TNF) membrane receptors 1 and 2 (sTNFR1 and sTNFR2) are present in body fluids. Their higher concentrations are observed in a number of diseases, including inflammatory bowel diseases (IBDs). sTNFR1 and sTNFR2 are capable of binding TNF-α, acting as an inhibitor that competes with a membrane receptor. The results of the available studies on s...

A novel beta-cyclodextrin (beta-CD) derivative modified with a degradable and biocompatible oligo(lactic acid) (OLA) group, 6-oligo(lactic acid)cyclomaltoheptaose (6-OLA-beta-CD), was successfully synthesized and used as a chiral selector for the capillary electrophoretic (CE) resolution (R(s)) of several basic analytes. The primary purpose of the research was to explore the capability of the 6...

AIM To optimize the efficacy of noninvasive evaluations in monitoring the endoscopic activity of inflammatory bowel disease (IBD). METHODS Fecal calprotectin (FC), clinical activity index (CDAI or CAI), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and procalcitonin (PCT) were measured for 136 IBD patients. Also, FC was measured in 25 irritable bowel syndrome (IBS) patients ...

In this work we study integral boundary value problem involving Caputo differentiation  cD tu(t) = f(t, u(t)), 0 < t < 1, αu(0)− βu(1) = ∫ 1 0 h(t)u(t)dt, γu′(0)− δu′(1) = ∫ 1 0 g(t)u(t)dt, where α, β, γ, δ are constants with α > β > 0, γ > δ > 0, f ∈ C([0, 1]×R+,R), g, h ∈ C([0, 1],R+) and cD t is the standard Caputo fractional derivative of fractional order q(1 < q < 2). By using some fix...

Citation: Lei L, Lv H, Yu Y, Hu R, Wang R, Xu Y, Ding Y, Feng R and Fan Z (2018) Performances of Water Management, Foliage Dressing, and Variation Screening in Controlling the Accumulation of As and Cd and Maintaining the Concentrations of Essential Elements in the Grains of Rice Plant. Front. Environ. Sci. 6:3. doi: 10.3389/fenvs.2018.00003 Performances of Water Management, Foliage Dressing, a...

Background. Syndecan-1 (SDC-1), a member of the family of heparan sulfate proteoglycans, plays an important role in the resolution of inflammation. This study aimed to investigate the relationship between SDC-1 and disease activity in Crohn's disease (CD). Methods. Serum samples of 54 patients with CD and 30 healthy controls were obtained. First, SDC-1 levels of the CD patients were compared to...

In this thesis we introduce a ∆-set Ψ d (R )• which we regard as the piecewise linear analogue of the space Ψd(R ) of smooth d-dimensional submanifolds in R introduced by Galatius in [4]. Using Ψ d (R )• we define a bi-∆-set Cd(R )•,• whose geometric realization BC d (R ) = ∥∥Cd(RN )•,•∥∥ should be interpreted as the PL version of the classifying space of the category of smooth d-dimensional co...

Reported findings on cortisol reactivity to stress in young people with ADHD are very variable. This inconsistency may be explained by high rates of comorbidity with Conduct Disorder (CD). The present study examined cortisol responses to a psychosocial stressor in a large sample of adolescent males with ADHD (n=202), with or without a comorbid diagnosis of Conduct Disorder (CD). Associations be...

Abstract Background In Crohn’s disease (CD) Smad7 is overexpressed in the intestinal mucosa, where it contributes to a sustained production of inflammatory cytokines, increased matrix metalloproteinase (MMP) activity and chronic inflammation through inhibition anti-inflammatory actions TGF-beta. GED-0301, an anti-sense oligodeoxynucleaotide complementary mRNA Smad7, inhibits translation synthes...