NK cells are the dominant population of immune cells in the endometrium in the secretory phase of the menstrual cycle and in the decidua in early pregnancy. The possibility that this is a site of NK cell development is of particular interest because of the cyclical death and regeneration of the NK population during the menstrual cycle. To investigate this, we searched for NK developmental stage...

Metastasis is the primary cause of cancer patient morbidity and mortality, but due to persisting gaps in our knowledge, it remains untreatable. Metastases often occur as patient tumors progress or recur after initial therapy. Tumor recurrence at the primary site may be driven by a cancer stem-like cell or tumor progenitor cell, while recurrence at a secondary site is driven by metastatic cancer...

Dermatofibrosarcoma protuberans (DFSP) is a malignant cutaneous tumor with a high rate of recurrence. Nevertheless, it responds to the drug Imatinib. The pathogenic mechanism why this drug works seems to be different to the inhibition of the Kit receptor of tyrosine kinase, since DFSP has repeatedly failed to express CD117 when immunohistochemically tested. Due to previous reports that claimed ...

In patients with mastocytosis, gastrointestinal symptoms are a frequent phenomenon. However, there are only limited data about the quantity and distribution pattern of mast cells in the gastrointestinal mucosa. We stained gastroduodenal biopsy specimens from 27 patients with mastocytosis and 48 control subjects for mast cell tryptase, CD117, and CD25. The numbers of mucosal mast cells per high-...

Reported herein is a coexistence of renal cell carcinoma in a gastrointestinal stromal tumor (GIST) patient. A 77-year-old male suffered from renal tubulocystic carcinoma in the left kidney and spindle cell gastrointestinal stromal tumors. Immunohistochemically, the renal cancer cells showed expression of Vimentin, Ckpan, CK18, CK19, CD10, P504S and Pax-8, focal positive of CK7, 34βE12, Ksp-cad...

Precise replacement of diseased or dysfunctional organs is the goal regenerative medicine and has appeared to be a distant for long time. In field hematopoietic stem cell transplantation, this now becoming tangible as gene-editing technologies novel conditioning agents are entering clinical arena. Targeted immunologic depletion cells (HSCs), which at very root system, will enable more selective...

Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors arising from the wall of the gastrointestinal tract with immunohistochemical reactivity for CD117 antibody, and usually prevalent in the fifth to seventh decade of life. The specific practical diagnostic criteria for GIST are c-kit expression (CD117), mitotic score, and the tumour size. The stomach is the most common site of lo...