نتایج جستجو برای: cd95l
تعداد نتایج: 278 فیلتر نتایج به سال:
Dengue is a disease caused by dengue virus (DENV) that transmitted mainly the female Aedes aegypti mosquito. There are four serotypes of DEN, leading to possibility person may be infected times this virus, albeit with different serotypes. Recovery from infection one viral serotype provides lifelong immunity same but not other Secondary increases risk developing severe dengue. The pathogenesis i...
Stimulation of CD95/Fas drives and maintains cancer stem cells (CSCs). We now report that this involves activation of signal transducer and activator of transcription 1 (STAT1) and induction of STAT1-regulated genes and that this process is inhibited by active caspases. STAT1 is enriched in CSCs in cancer cell lines, patient-derived human breast cancer, and CD95high-expressing glioblastoma neur...
We used immunohistochemistry and flow cytometry to assess apoptosis in human glioblastoma multiforme (GBM). Our immunohistochemical study revealed apoptosis of glioma cells expressing glial fibrillary acidic protein and of CD3(+) T cells infiltrating GBM. To quantify and phenotype the apoptotic T cells, we performed flow cytometry on lymphocytes separated from GBM. The cells were stained with a...
The regulation of cellular survival and apoptosis is of critical importance for the immune system to maintain immune homeostasis and to establish tolerance. Here, we demonstrate that the immune specific cell surface molecule Toso exhibits antiapoptotic effects on death receptor signaling by a novel regulatory mechanism involving the adaptor kinase RIP1. The antiapoptotic function of Toso depend...
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