Case presentation: 4 year-old male, diagnosed with Cornelia de Lange syndrome (CdLS). Born preterm at 35 weeks of gestation, the baby weighted 1670 kg and remained in ICU for 25 days. At 1 year age he presented a cephalic perimeter 44cm (microcephaly), horizontal nystagmus extreme lateral gaze, slow saccades, hypertonia hyperreflexia on all four limbs dysmorphic features (hypertelorism, wide no...

Neste artigo, apresentamos como mobilizamos a adaptação proposta por Swiderski e Costa-Hübes (2009) da sequência didática (SD) originalmente formulada Dolz, Noverraz Schneuwly (2004), com vistas atingir objetivos delineados partir de nosso contexto. As intervenções basearam-se no Interacionismo Sociodiscursivo, em que o gênero é tido instrumento para desenvolvimento capacidades linguagem. Nosso...

This paper proposes a probabilistic modeling learning algorithm for the local search approach to the Multiple-Valued Logic (MVL) networks. The learning model (PMLS) has two phases: a local search (LS) phase, and a probabilistic modeling (PM) phase. The LS performs searches by updating the parameters of the MVL network. It is equivalent to a gradient decrease of the error measures, and leads to ...

Reliable and accurate reference intervals (RIs) for laboratory analyses are an integral part of the process of correct interpretation of clinical laboratory test results. RIs given in laboratory reports have an important role in aiding the clinician in interpreting test results in reference to values for healthy populations. Since the 1980s, the International Federation of Clinical Chemistry (I...

Adaptation to seasonal changes in the northern hemisphere includes an ability to predict the forthcoming cold season from gradual changes in environmental cues early enough to prepare for the harsh winter conditions. The magnitude and speed of changes in these cues vary between the latitudes, which induces strong selection pressures for local adaptation.We studied adaptation to seasonal changes...

Robert syndrome (RBS) and Cornelia de Lange syndrome (CdLS) are human developmental disorders characterized by craniofacial deformities, limb malformation, and mental retardation. These birth defects are collectively termed cohesinopathies as both arise from mutations in cohesion genes. CdLS arises due to autosomal dominant mutations or haploinsufficiencies in cohesin subunits (SMC1A, SMC3 and ...

w ED1 + lmacmphages, monocytes and dendritic cellsl and ED2+ cells ImacrophaQoa ordvl agpear to have a role in comeal rejection followinp pen&ti~ kerato&~~ in the rat. In the fdlowinp presentation the distribution of ED1 and ED2 wsitive cdls in normal weal tissues of Lewis rats, the influence of comeal transpiantation and the efIeci of Cwlnspuin A lCsAl upon both types of wllr was examined. m 6...

w ED1 + lmacmphages, monocytes and dendritic cellsl and ED2+ cells ImacrophaQoa ordvl agpear to have a role in comeal rejection followinp pen&ti~ kerato&~~ in the rat. In the fdlowinp presentation the distribution of ED1 and ED2 wsitive cdls in normal weal tissues of Lewis rats, the influence of comeal transpiantation and the efIeci of Cwlnspuin A lCsAl upon both types of wllr was examined. m 6...