Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA-3C) is essential for EBV-mediated immortalization of human B lymphocytes and regulates both the cell cycle and transcription. Transient reporter gene assays have implicated a pivotal role for EBNA-3C in the regulation of transcription of the majority of latency-associated genes expressed during the EBV growth program, including the viral oncopro...

Chronic pancreatitis is characterized by longterm progressive inflammation of the pancreatic gland, leading to permanent deterioration of its structure and to development of malabsorption, debilitating pain and diabetes mellitus. The annual incidence of the disease has been estimated to 5-10 per 100,000 persons in Western countries. The persistent pancreatic inflammation also confers a high ris...

The Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA-3C) protein is a transcriptional regulator of viral and cellular genes that is essential for EBV-mediated immortalization of B lymphocytes in vitro. EBNA-3C can inhibit transcription through an association with the cellular DNA-binding protein Jkappa, a function shared by EBNA-3A and EBNA-3B. Here, we report a mechanism by which EBNA-3C can ...

We compare Temporal Difference Learning (TDL) with Coevolutionary Learning (CEL) on Othello. Apart from using three popular single-criteria performance measures: i) generalization performance or expected utility, ii) average results against a hand-crafted heuristic and iii) result in a head to head match, we compare the algorithms using performance profiles. This multi-criteria performance meas...

The goal of the study reported in the paper was to determine whether rendering style (non-photorealistic versus realistic) has an effect on perception of American Sign Language (ASL) finger spelling animations. Sixty-nine (69) subjects participated in the experiment; all subjects were ASL users. The participants were asked to watch forty (40) sign language animation clips representing twenty (2...

Picture 1. Biopsy of the neck lymph node. (A) Difuse medium cel lymphoma (mantle cel lymphoma) (HE stain). (B) Positive immunostaining of lymphoma cels with anti-cyclin D1 antibody. Picture 2. Formalin-fixed (A) right and (B) left lungs showing major bronchi with marked thickening of the wal and a pencil lead caliber. MB, main bronchus; ULB, upper lobe bronchus; MLB, middle lobe bronchus; LLB, ...

aLaboratório de Dinâmicas Ecológicas, Departamento de Zoologia, Universidade Federal do Paraná – UFPR, Av. Cel. Francisco Heráclito dos Santos, s/n, Jardim das Américas, CP 19020, CEP 81530-980, Curitiba, PR, Brazil bLaboratório de Biologia Comparada de Hymenoptera, Departamento de Zoologia, Universidade Federal do Paraná – UFPR, Av. Cel. Francisco Heráclito dos Santos, s/n, Jardim das Américas...

BACKGROUND Thermochemical pretreatment of lignocellulose is crucial to bioconversion in the fields of biorefinery and biofuels. However, the enzyme inhibitors in pretreatment hydrolysate make solid substrate washing and hydrolysate detoxification indispensable prior to enzymatic hydrolysis. Sulfite pretreatment to overcome recalcitrance of lignocelluloses (SPORL) is a relatively new process, bu...