Abstract Mixed phenotype acute leukemia (MPAL) is an uncommon disease characterized by currently only limited knowledge concerning biology, clinical presentation, and treatment outcome. We here describe a most unusual case of simultaneous occurrence T-lymphoblastic lymphoma in cervical mediastinal lymph nodes myeloid the bone marrow (BM) successfully treated with allogeneic stem cell transplant...

Apoptosis is an evolutionarily conserved sequential process of cell death to maintain a homeostatic balance between formation and death. It vital for normal eukaryotic development as it contributes the renewal cells tissues. Further, plays crucial role in elimination unnecessary through phagocytosis prevents undesirable immune responses. regulated by complex signaling mechanism, which driven in...

INTRODUCTION Merkel cell carcinoma is a neuroendocrine malignancy. Suppressor of fused (SUFU) is a tumor suppressor oncogene that participates in the Hedgehog (Hh) signaling pathway. The aim of the study was to describe a patient whose Merkel cell carcinoma demonstrated a SUFU genomic alteration. CASE STUDY The Hh signaling pathway is involved in the pathogenesis of several tumors, including ...

Background: Most of our current understanding of the biological effects of exposure to ionising radiation is based on conventional cytogenetic techniques, which enable us to determine the relationship between chromosomal aberration and dose received by radiation workers. However, conventional techniques have numerous limitations and chromosomal aberrations can be easily missed. Since FISH plays...

AIM To compare higher order aberrations in two aspherical intraocular lenses (IOLs): Akreos advanced optics (AO) and Dr. Schmidt Microcrystalline 6125 aspheric anterior surface (MC6125AS) with each other. METHODS Forty eyes of 39 patients underwent phacoemulsification and Akreos AO and MC6125AS were implanted in their eyes in a random manner. Three months post-operatively, higher order aberra...

The wave-front aberration of the human eye was measured for eight subjects using a spatially resolved refractometer (a psychophysical ray-tracing test). The eyes were undilated and presented with accommodative stimuli varying from 0 to -6 diopters. Monochromatic wave-front aberrations tend to increase with increasing levels of accommodation, although there are substantial individual variations ...

The resolution of a scanning transmission electron microscope remains 100 times worse than its theoretical limit owing to the spherical aberration of objective lens. Ikuta proposed a system to generate an aberration-free amplitude image and phase image using multiple small detectors with real-time signal processing. This study shows the performance optimization results of its signal processing ...

The initial announcement of two successful alternative geometries of successful aberration correctors for TEM [1] and STEM [2] in 1997 has led to significant improvements in spatial resolution and the availability of higher probe current densities for analysis. There are now in excess of 400 aberration correctors installed worldwide. The Oxford-JEOL 2200MCO was the first instrument fitted with ...

We extend the method for the automatic computation of high-order optical aberration coefficients to include (1) a finite object distance and (2) an infinite entrance pupil position (telecentricity in object space). We present coefficients of the power series expansion of the transverse aberration vector with respect to the normalized aperture and field coordinates. Aberration coefficients of ve...