which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 43-year-old man presented with lower abdominal pain. Initial values of laboratory examinations were as follows: osteolytic lesions in the right 6 th rib and right ilium. Serum protein electrophoresis (PEP) showed no specific finding, but urine PEP revealed...

The cell walls of three species of rumen bacteria (Bacteroides ruminicola, Bacteroides succinogenes, and Megasphaera elsdenii) were studied by a variety of morphological methods. Although all the cells studied were gram-negative and had typical cytoplasmic membranes and outer membranes, great variation was observed in the thickness of their peptidoglycan layers. Megasphaera elsdenii evidenced a...

Although the role of the actin cytoskeleton in morphogenesis of polarized epithelial sheets is generally accepted as centrally important, the regulation of actin dynamics in this process remains unclear. Here, we show that the pointed-end capping protein Tmod3 contributes to epithelial cell shape within confluent monolayers of polarized epithelial cells. Tmod3 localizes to lateral cell membrane...

Under physiologic conditions a small percentage ( 3%) of red blood cells (RBCs) are irreversibly trapped within the fibrin clot mesh. By contrast, in prothrombotic states such as diabetes mellitus, significantly more RBCs are tightly bound to fibrin fibers. Such interactions affect clot properties, making it more resistant to fibrinolytic degradation. This phenomenon may explain thrombolytic re...