The nucleotide-binding domain and leucine-rich-repeat-containing family (NLRs) (sometimes called the NOD-like receptors, though contains few bona fide receptors) are a superfamily of multidomain-containing proteins that detect cellular stress microbial infection. They constitute critical arm innate immune response, their functions not restricted to pathogen recognition members engage in control...

Abstract FERONIA (FER) is a member of the Catharanthus roseus receptor-like kinase 1-like (CrRLK1L) protein subfamily, which participates in reproduction, abiotic stress, biotic cell growth, hormone response, and other molecular mechanisms plants. However, mechanism by single RLK capable mediating multiple signals activating cellular responses remains unclear. Here, we summarize research progre...

Abstract: Intracellular tryptophan (Trp) is catabolized to a large repertoire of metabolites via two major pathways: indoleamine and 2, 3-dioxygenases (IDO/TDO) Trp hydroxylase (TPH) pathways. The catabolites possess diverse biological activities carry out various physiological functions. Several such as kynurenine (Kyn) serotonin promote while melatonin 5-methoxytryptophan (5-MTP) suppress can...

Several stimuli can change maternal hormone levels during pregnancy. These changes may affect trophoblastic cells and modulate the development of embryo placental tissue itself. Changes in cortisol are associated with impaired trophoblast implantation function, addition to other pregnancy complications. This study aims analyze effects low high doses on an extravillous cell line, various exposur...

background and objective: breast cancer is the commonest cancer of indian women. estrogen and progesterone expression is seen in benign breast lesions and in breast carcinoma associated with good prognostic parameters and it correlates well with response to hormone therapy. although a lot of studies have been conducted in the past on hormone receptor expression in breast cancer and few have cor...

conclusions p. gingivalis and p. intermedia could play a role in implant failure by changing the expression profiles of genes related to bone formation and resorption. results viability was reduced to 56.8% (p. gingivalis) and 52.75% (p. intermedia) at 1000 multiplicity. amongst 48 genes examined, expressions of bmper, smad1, il8 and nfrkb were found to be highly upregulated by both bacterial c...