SUMMARY X. Pis a rare autosomal recessive genodermatosis characteriseJ by photophohia, severe solar sensitivity, cutaneous pigmentary changes, xerosis and early Jevdopment of mucocutaneous and ocular cancer particularly in sun exposeJ skin. Tumors whichinclude solar keratosis, cutaneous horn, keratoachanthoma, squamous and basal cell carcinoma, malignant melanoma and angioma may developeJ in...

objective(s):multidrug resistance (mdr) of cancer cells is a major obstacle to successful chemotherapy. overexpression of breast cancer resistance protein (bcrp) is one of the major causes of mdr. in addition, it has been shown that pi3k/akt signaling pathway involves in drug resistance. therefore, we evaluated the effects of novel approaches including sirna directed against bcrp and targeted t...

we evaluated the ability of spectral-domain optic coherence tomography (sd-oct) to differentiate large physiological optic disc cupping (lpc) from glaucomatous cupping in eyes with intraocular pressure (iop) within the normal range.â  we prospectively enrolled patients with glaucoma or presumed lpc. participants â had optic discs with confirmed or suspected glaucomatous damage (defined as a ver...

Background: Single-cell RNA sequencing (scRNA-seq) technology is now becoming a widely applied method of transcriptome exploration that helps to reveal cell-type composition as well cell-state heterogeneity for specific biological processes. Distinct platforms and processing pipelines may contribute various results even the same samples. Therefore, benchmarking was considered necessary s...