background and objectives: oxidative stress is implicated in the neuronal damage associated with alzheimer’s disease, parkinson’s disease, huntington’s disease, amyotropic lateral sclerosis and cerebral ischemic stroke. the present work was designed to establish the neuroprotective effects of salvia aristata extract on h2o2-induced apoptosis in human dopaminergic sh-sy5y cells. methods: the tot...

Sulfonamides are the first effective chemotherapeutic agents used for several years to cure or prevent systemic bacterial infections. In addition, this agents showed anti-carbonic anhydrase and cause cell cycle perturbation in the G1 phase, disruption of microtubule assembly, suppression of the transcription activator Nf-Y, angiogenesis and matrix metalloproteinase (MMP). In recent years, novel...

Background: During the first trimester of pregnancy the uterine spiral arteries that supply blood to the placenta are remodelled, creating heavily dilated conduits lacking maternal vasomotor control. To effect permanent vasodilatation, the internal elastic lamina and medial elastic fibres must be degraded. Failure of remodelling is a key characteristic of the pathological placenta and is though...

BACKGROUND The use of pulsed electric fields (PEFs) to irreversibly electroporate cells is a promising approach for destroying undesirable cells. This approach may gain enhanced applicability if the intensity of the PEF required to electrically disrupt cell membranes can be reduced via exposure to a molecular deliverable. This will be particularly impactful if that reduced PEF minimally influen...

Multiple sclerosis (MS) is a chronic autoimmune disorder of central nervous system. This demyelinating disease affects more than 2.3 million people world wild. Most of patients are young adult. There are many possible triggering factors including infections, toxin, immunization, trauma, sunlight exposure and hormonal variable in pathogenesis of MS. One of the important trigger is stress. There ...

Background: The mechanism of para-nonylphenol (PNP) reducing the proliferation and differentiation of bone marrow mesenchymal stem cells (MSCs) is not known. The present study was designed to investigate the mechanism. Methods: MSCs were extracted under sterile condition from Wistar rat and cultured in DMEM, containing 15 % FBS and penicillin/streptomycin until the 3rd passage, then cells we...

Abstract Staphylococcal nuclease domain-containing protein 1 (SND1) is a multifunctional oncoprotein overexpressed in breast cancer. Binding of metadherin (MTDH) to SND1 results the stabilization and important initiation progression Disruption such interaction potential therapeutic for SN1/2 domain was used as bait phage display screening identify 12-amino acid peptide 4-2. The activity 4-2 eva...

Tissue regeneration and maintenance rely on coordinated stem cell behaviors. This orchestration can be impaired by oncogenic mutations leading to tissue architecture disruption ultimately cancer formation. However, it is still largely unclear how oncogenes perturb cells’ functions break architecture. Here, we utilized intravital imaging novel signaling reporter investigate the mechanisms of Kra...

Appropriately targeted manipulation of endogenous neural stem progenitor (NSP) cells may contribute to therapies for trauma, stroke, and neurodegenerative disease. A prerequisite to such therapies is a better understanding of the mechanisms regulating adult NSP cells in vivo. Indirect data suggest that endogenous ciliary neurotrophic factor (CNTF) receptor signaling may inhibit neuronal differe...

Tetraselmis is an interesting microalga for food products because of its high protein content and surface productivity as well the possibility to scale up culture easily. However, this specie yet understudied compared other algae such Chlorella. Different batches chui were received from same supplier, with different morphological properties, probably associated a difference in physiological sta...