this scientific report describes the effect of feeding detoxified karanj seed cake as protein replacement of soya bean meal on immunity and pathology in growing lambs. twenty-four male lambs, 4-6 months of age were divided into four groups of six each and fed with different levels of detoxified karanj seed cake (dkc 0%, dkc 25%, dkc 50%, dkc 75%) for 140 days. effect on humoral and cell mediate...

Under conditions of naturally acquired primary varicella-zoster virus (VZV) infection, the first response of the naive host is mediated by the innate immune system through antiviral cytokines and the activation of NK cells [1]. These responses are likely to be important for the initial control of VZV at mucosal sites of inoculation and to trigger the induction and amplification of adaptive, VZV...

Recent studies have radically changed our views of the development of acquired immunity during gestation and perinatal life. It is now apparent that there are considerable differences in the way the immune response matures in different species (Sterzl and Silverstein, 1967; Adinolfi and Wood, 1969; Solomon, 1971). In mice and rats immune reactions are relatively immature even in the newborn. In...

Centchroman (Ormeloxifene) is a nonsteroidal selective estrogen receptor modulator that is used as once a week oral contraceptive agent. The effect of centchroman on the immune system was evaluated by using different experimental models such as carbon clearance test, cyclophosphamide induced neutropenia, neutrophil adhesion test, effect on serum immunoglobulins, mice lethality test and indirect...

Recent studies have radically changed our views of the development of acquired immunity during gestation and perinatal life. It is now apparent that there are considerable differences in the way the immune response matures in different species (Sterzl and Silverstein, 1967; Adinolfi and Wood, 1969; Solomon, 1971). In mice and rats immune reactions are relatively immature even in the newborn. In...

The genus Bartonella includes important human-specific and zoonotic pathogens which cause intraerythrocytic bacteremia in their mammalian reservoir host(s). It is accepted that cellular immunity plays a decisive role in the host's defense against most intracellular bacteria. Bartonella sp. infection in the immunocompetent host typically leads to immunity against homologous challenge. The basis ...

Chronic equine laminitis causes persistent pain and lameness in affected animals and often necessitates euthanasia when pain management strategies become ineffective. Published studies as well as anecdotal reports suggest that this chronic inflammatory disease is associated with systemic alterations in immune responsiveness, perhaps involving an autoimmune component. We investigated this broad ...

A close association of autoimmune diseases or autoimmune phenomena in myasthenia gravis is well known. A comprehensive immunological study of 22 patients with myasthenia gravis showed that changes in the immune system mainly involve the thymus-derived lymphocytes (T cells). Anti-thymus antibody was present in 90% of the patients, and it paralleled the frequency of thymic abnormality in myasthen...

The persistence of humoral and cellular immunity to varicella-zoster virus (VZV) was evaluated in 60 children and 18 adults immunized with live attenuated VZV vaccine. At a mean of 5 years after vaccination, 93% of children and 94% of adults had IgG antibodies to VZV as determined by ELISA. VZV antibody concentrations were significantly higher at 5 years than at 1 year after immunization in chi...

Objective: The immunomodulatory effect of geranial, geranial acetate, gingerol, and eugenol essential oils were evaluated by studying humoral and cell-mediated immune responses. Materials and Method: The essential oils were evaluated for immunomodulatory activity in in vivo studies, using rats as the animal model. The essential oils were tested for hypersensitivity and hemagglutination reaction...