The purpose of this study was to develop the surface modification of docetaxel nanocrystals (DTX-NCs) with apo-Transferrin human (Tf) for improving the cellular uptake and cytotoxicity of DTX. DTX-NCs were prepared by a nanoprecipitation method, and the surface modified with Tf by an adsorption method (Tf-DTX-NCs). The morphology and particle size of DTX-NCs and Tf-DTX-NCs were characterized us...

Immune tolerance induced by regulatory mechanisms is an integral and fundamental part of immunity. In therapeutic settings, however, tolerance may significantly limit efficacy. Here, we summarize possible strategies to enhance therapeutic antibody dependent cellular cytotoxicity by overcoming NK cell tolerance.

Cell Chirality Assays In article 2101088, Wan and co-workers review the characterization of cellular chirality or handedness which can be used for cytotoxicity assessment. The cells display directional alignment within well-confined geometric boundaries in normal conditions, such as ring-shaped micropatterns. toxic environments, cell may exhibit a reversed bias become randomized. This new type ...