the traditional fuzzy operators, such as t-norms, t-conorms and averaging operators have been used for soil suitability evaluation to aggregate criteria as an overall suitability index. however, such operators do not account for the degree of compensation common to human aggregation criteria, especially in the presence of conflicting criteria. fuzzy integrals are powerful and flexible aggregati...

Exploration into morphofunctional organisation of centromere DNA sequences is important for understanding the mechanisms of kinetochore specification and assembly. In-depth epigenetic analysis of DNA fragments associated with centromeric nucleosome proteins has demonstrated unique features of centromere organisation in chicken karyotype: there are both mature centromeres, which comprise chromos...

Centromeric DNA, being highly repetitive, has been refractory to molecular analysis. However, centromeric structural proteins are encoded by single-copy genes, and these can be analyzed by using standard phylogenetic tools. The centromere-specific histone, CenH3, replaces histone H3 in centromeric nucleosomes, and is required for the proper distribution of chromosomes during cell division. Wher...

In human chromosomes, centromeric regions comprise megabase-size arrays of 171 bp alpha-satellite DNA monomers. The large distances spanned by these arrays preclude their replication from external sites and imply that the repetitive monomers contain replication origins. However, replication within these arrays has not previously been profiled and the role of alpha-satellite DNA in initiation of...

UNLABELLED Telomeres and centromere are two essential features of all eukaryotic chromosomes. They provide function that is necessary for the stability of chromosomes. We developed a comprehensive database named TeCK, which covers a gamut of sequence and other related information about telomeric patterns, telomere repeat sequences, centromere sequences and centromeric patterns present in chromo...

Male rats were treated of with a diet supplemented daily by the synthetic food colour erythrosine (0.08 and 0.4 g/kg diet) for 30 days. Changes in mutagenic activities, as an index for evaluating of possible toxic effects, were monitored by measuring chromosomal aberrations of rat bone marrow, nucleic acids and total protein concentrations of rat liver and brain. The present study found that er...

proteins, such as transcription factors, bind selectively to DNA via short but highly conserved binding sites, a second class of factors such as yeast centromere binding factor III (CBF3; Espelin et al., 1997) and the origin recognition complex (ORC) bind to large, poorly conGarth R. Wiens and Peter K. Sorger Department of Biology Massachusetts Institute of Technology Cambridge, Massachusetts 0...