The present study explores the contribution of alterations in resting tone to cerebral artery narrowing in SHRs (spontaneously hypertensive rats) and the role of hypertension development. Young pre-hypertensive and adult fully hypertensive SHRs and age-matched Wistar-Kyoto rat controls were used. The contribution of basal vasoactive factors to resting tone was studied in middle cerebral arterie...

BACKGROUND AND PURPOSE Chronic hypertension decreases internal diameter of cerebral arteries and arterioles. We recently showed that short-term treatment with the angiotensin II receptor blocker telmisartan restored baseline internal diameter of small cerebral arterioles in spontaneously hypertensive rats (SHR), via reversal of structural remodeling and inhibition of the angiotensin II vasocons...

Recent morphological and functional studies on the circle of Willis suggest that the areas of supply of the six major cerebral arteries show a considerable variation in distribution, in contrast to the relatively consistent pattern generally accepted; therefore, the cortical and intracerebral distribution of the territories of these arteries was investigated in 25 unfixed human brains obtained ...

THE HISTOLOGY and histochemistry of cerebral arteries have been subject to only a few investigations. Duff, Forbus, Glynn, and Carmichaelhave stressed the importance of the integrity of the internal elastic membrane. Wolkoff studied the relationship between the elastic elements and ground substance components in cerebral arteries. He noted that lipid was occasionally seen between the reduplicat...

BACKGROUND AND PURPOSE Atherosclerotic middle cerebral arteries are frequent sites of thrombosis, leading to stroke. Previous studies have suggested a role for Chlamydia pneumoniae in the pathogenesis of atherosclerosis. However, the presence of this pathogen in atherosclerotic middle cerebral arteries has heretofore not been documented. In the present study, we analyzed atheromatous plaques fr...

abstract background: transcranial doppler ultrasonography results have not been previously studied in among iranian sickle cell anemia patients. the present study was performed to evaluate the pattern of intracranial flow velocities among iranian children with sickle cell anemia and the hematological parameters that can affect the time-averaged mean of maximum velocity in major intracranial art...

BACKGROUND AND PURPOSE Rat major cerebral arteries seem to receive serotonergic fibers originating from the dorsal raphe nucleus (DRN), but little is known about their function. The aim of our present work was to establish a functional relationship between this brain stem nucleus and the cerebral blood vessels by studying the effects of several treatments in the DRN on cerebrovascular serotoner...

We report an attempt to obtain images of the basal cerebral arteries and to measure the quantitative flow velocity in these arteries from outside the skull via the color Doppler imaging method. In 25 healthy volunteers, 22-41 years old, the transducer was positioned just superior to the zygomatic arch and anterior to the external ear canal. The absolute flow velocity was calculated by dividing ...

In this study the magnitude of non-sympathetic, non-cholinergic neurogenic vasodilation of feline cerebral arteries in vitro was correlated with the extent of innervation by VIP-immunoreactive nerves. Well-innervated arteries underwent nerve-mediated relaxation whereas those that are not supplied with VIP-containing axons did not relax to transmural nerve stimulation. The relaxation of cerebral...

BACKGROUND AND PURPOSE There is little information regarding the pathogenesis underlying diffuse myelin loss in the cerebral white matter and sparing of the U fibers in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), in which the medial smooth muscle cells of systemic arteries are characteristically involved. We sought to examine the precise...