نتایج جستجو برای: cervical tumor
تعداد نتایج: 510237 فیلتر نتایج به سال:
Malignant proliferation is the fundamental trait of tumor cells. The initiation of DNA replication represents a key process for cell proliferation, and has a marked impact on tumorigenesis and progression. Here we report that Sine oculis homeobox homolog 1 (SIX1) functions as a master regulator in DNA replication of cervical cancer cells. The expression of SIX1 was induced by the E7 oncoprotein...
Diffusion-weighted magnetic resonance imaging in predicting the radiosensitivity of cervical cancer.
This study investigates the application value of diffusion-weighted magnetic resonance imaging in predicting cervical cancer radiosensitivity. Twenty-five patients who were newly diagnosed as cervical cancer and accepted simple radiotherapy were included in this study. Before external irradiation, 20 GY and at the end of irradiation, routine 1.5 T MRI and diffusion-weighted magnetic resonance i...
AIMS To investigate the prognostic role of stomatin-like protein 2 (STOML2) in cervical cancer. METHODS The expression of STOML2 in 8 pairs of cervical cancer and adjacent normal cervical tissues were detected by Real-time PCR. Immunohistochemistry was performed to evaluation of STOML2 expression in 94 paraffin-embedded cervical cancer samples. The correlation between STOML2 expression and ce...
BACKGROUND Cervical cancer is a world-wide problem that requires transformative therapeutic strategies. We have previously developed patient-derived orthotopic xenograft (PDOX) nude-mouse models of this disease. In the present report, we demonstrate that the standard drug, cisplatinum (CDDP), is highly-effective while the new, highly-touted agent, nab-paclitaxel (NAB-PTX) is ineffective. MATE...
OBJECTIVE The purposes of this study were to establish intracervical tumors of the nude rat as an orthotopic experimental model for human cervical cancer and to preliminary evaluate the effects of the adenoviral vector, Ad5CMV-p53, on orthotopic cervical tumor size. METHODS Human cervical cancer SiHa and ME-180 cells were injected into the cervix of the nude rat. Four days later, 1 x 10(9) pl...
The development of cervical cancer is frequently accompanied by the integration of human papillomaviruses (HPV) DNA into the host genome. Viral-cellular junction sequences, which arise in consequence, are highly tumor specific. By using these fragments as markers for tumor cell origin, we examined cervical cancer clonality in the context of intra-tumor heterogeneity. Moreover, we assessed the p...
OBJECTIVE This study aimed to evaluate the relationship between forkhead box P3 (Foxp3) expression and clinicopathological characteristics of cervical cancer and to explore the influence of Foxp3 on the biological behaviors of cervical cancer cells. METHODS In this study, immunohistochemistry, lentivirus mediated transfection, Transwell assay; CCK-8 assay, real-time PCR and flow cytometry wer...
cystic hygroma (ch) in the cervical region presents as a challenge to the anesthetist. the anaesthetic difficulties are usually associated with ch because of tumor extension into the mouth, airway management, thoracic extension, hemorrhage, involvement of pretracheal region, post operative respiratory obstruction and coexisting anomalies (down syndromes, turner syndromes and congenital cardiac ...
BACKGROUND Abnormal Savda Munziq (ASMq), a traditional uyghur medicine, has shown anti-tumour properties in vitro. it was showed that total flavonoids of ASMq could inhibit the proliferation and enhance the antioxidant ability of human cervix cancer HeLa cell. This study attempts to confirm these effects on the transplanted cervical cancer (U27) mouse model in vivo. METHODS Forty eight Kunmin...
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