نتایج جستجو برای: chemotypes

تعداد نتایج: 676  

2006
S. U. MORATH P. D. PRATT C. S. SILVERS T. D. CENTER

WequantiÞed thedensity-dependent effects of herbivory by thepsyllidBoreioglycaspis melaleucae Moore on the senescence of expanding and fully expanded leaves from two chemical variants (chemotypes) of the invasive tree Melaleuca quinquenervia (Cav.) S. T. Blake. Foliar chlorophyll content (OD) and percent nitrogen were not inßuenced by leaf age classes and chemotypes. In contrast, increases in t...

Journal: :Infection and immunity 1999
A Lentschat V T El-Samalouti J Schletter S Kusumoto L Brade E T Rietschel J Gerdes M Ernst H Flad A J Ulmer

The prerequisites for the initiation of pathophysiological effects of endotoxin (lipopolysaccharide [LPS]) include binding to and possibly internalization by target cells. Monocytes/macrophages are prominent target cells which are activated by LPS to release various pro- and anti-inflammatory mediators. The aim of the present study was to establish a new method to determine the binding and inte...

Journal: :Memorias do Instituto Oswaldo Cruz 2009
Ana Cecilia Mesa-Arango Jehidys Montiel-Ramos Bibiana Zapata Camilo Durán Liliana Betancur-Galvis Elena Stashenko

Two essential oils of Lippia alba (Mill.) N.E. Brown (Verbenacea), the carvone and citral chemotypes and 15 of their compounds were evaluated to determine cytotoxicity and antifungal activity. Cytotoxicity assays for both the citral and carvone chemotypes were carried out with tetrazolium-dye, which showed a dose-dependent cytotoxic effect against HeLa cells. Interestingly, this effect on the e...

2014
Moses S. Owolabi Lawal A. Oladipupo Labunmi Lajide Rebecca M. Hauser William N. Setzer

The leaf essential oil of Croton zambesicus growing in Odogbolu, Ogun State, Nigeria, was obtained and analyzed by GC-MS. The leaf oil was dominated by the sesquiterpenoids -caryophyllene (8.8%) and caryophyllene oxide (21.7%), the monoterpenoids linalool (6.2%) and camphor (5.9%), and the diterpenoident-trachyloban-3-one (8.1%). A numerical cluster analyses has revealed at least two chemotype...

Journal: :SLAS DISCOVERY: Advancing the Science of Drug Discovery 2017

2016
Jassy Drakulic Mohd Haziq Kahar Olubukola Ajigboye Toby Bruce Rumiana V. Ray

Fusarium graminearum is the predominant causal species of Fusarium head blight in Europe and North America. Different chemotypes of the species exist, each producing a plethora of mycotoxins. Isolates of differing chemotypes produce nivalenol (NIV) and deoxynivalenol (DON), which differ in toxicity to mammals and plants. However, the effect of each mycotoxin on volatile emissions of plant hosts...

2015
Archana P. Raina K. S. Negi

Valeriana jatamansi Jones germplasm collected from sub-temperate Himalayan region of Uttarakhand and North-East state of Meghalaya, India was evaluated under identical conditions at National Bureau of Plant Genetic Resources, Bhowali, India, to study germplasm diversity based on essential oil composition. Twenty one compounds were identified in V. jatamansi root oil by GC and GC-MS. The major c...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Donna M Huryn Jeffrey L Brodsky Kay M Brummond Peter G Chambers Benjamin Eyer Alex W Ireland Masaoki Kawasumi Matthew G Laporte Kayla Lloyd Baptiste Manteau Paul Nghiem Bettina Quade Sandlin P Seguin Peter Wipf

Unique chemical methodology enables the synthesis of innovative and diverse scaffolds and chemotypes and allows access to previously unexplored "chemical space." Compound collections based on such new synthetic methods can provide small-molecule probes of proteins and/or pathways whose functions are not fully understood. We describe the identification, characterization, and evolution of two suc...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید