myeloid sarcoma of female breast is a rare presentation of acute myeloid leukemia (aml). the tumor mass may precede or occur concurrently with aml, cml, myeloproliferative disorders, and/or myelodysplastic syndromes. histologically, it looks like a large cell lymphoma and can be misdiagnosed. a case referred as a suspected case of large cell lymphoma. initial morphological study with convention...

Leukemia is the most common malignancy of childhood. Chloromas are rare presentations of underlying leukemic disease. It is important to diagnose these cases early in the course as they respond more favourably to focal irradiation. We present a rare case of chloroma of orbit in a young male patient who presented with severe proptosis and a large mass involving the left orbit. The orbital lesion...

BACKGROUND Differences in the clinical course of secondary acute myeloid leukemia according to the type of the preceding disorders are not defined. We compared the outcomes of therapy-related acute myeloid leukemia, acute myeloid leukemia following myelodysplastic syndrome and acute myeloiod leukemia following myeloproliferative neoplasm. We also intended to find prognostic factors in secondary...

Abnormalities of the thyroid gland are among the most frequent endocrine complications observed in childhood cancer survivors. We report an 11 years old girl who developed central hypothyroidism and ACTH deficiency during the chemotherapy for CNS relapse of acute lymphoblastic leukemia before receiving radiotherapy. Keywords: Thyroid gland, hypothyroidism, chemotherapy, acute lymphoblastic leu...

The frequency of acute lymphoblastic leukemia (ALL) patients expressing myeloid antigens on their ALL cells varies between 5 and 36% in several different studies. The clinical relevance of myeloid antigen expression in childhood ALL is controversial. In Indonesian patients, no data were present. Therefore, in Yogyakarta, Indonesia, we analyzed 239 ALL patients who were immunophenotyped includin...

introduction: about half of acute myeloid leukemia (aml) adult patients have no cytogenetic abnormalities as a main determinant of complete remission after treatment, so other markers are needed such as flt3-itd (fms-like tyrosine kinase3-internal tandem duplication) mutations in patients with normal karyotype. the objective of this study was assessing the frequency of flt3-itd mutations and it...

BACKGROUND Acute myeloid leukemia is typically a disease of the older population and presents mostly in the fifth decade of life. Myeloid sarcoma is a rare initial presentation of acute myeloid leukemia. Previously it has only been documented in children and younger patients. CASE PRESENTATION We present an unusual case of retro-orbital myeloid sarcoma as an initial presentation of acute myel...

acute myeloblastic leukemia is one of the important malignancies in children. for better managing the prognosis of this disease, there should be enough information about common features of this malignancy. the aim of this study was to evaluate these common features in children with acute myeloblastic leukemia. a total of 104 eligible children less than 15-year-old have been referred from 2007-2...

post-remission treatment in patients with acute myeloid leukemia is still controversial. one potent choice for patients with no donor available is autologous stem cell transplantation. the median follow-up period was 18 months and the median age was 26 years old. in the review of 116 recently diagnosed aml patients (except aml- m3) who underwent autologous stem cell transplantation, 72.4% of pa...