Transient neonatal myasthenia gravis is a rare disease; it affects an estimated 15% of all babies born to myasthenic mothers. Since the condition was first described by Strickroot, Schaeffer, and Bergo (1942), reports have appeared in English of 42 patients, 4 of whom died in the neonatal period. Intestinal smooth muscle hypertrophy is extremely rare in infancy and childhood; to our knowledge o...

OBJECTIVES To study mortality and survival of patients with myasthenia gravis. METHODS 290 patients with myasthenia gravis were studied, including 212 incident cases identified during a comprehensive epidemiological study of myasthenia gravis in western Denmark 1975-89. Follow up was performed on 31 December 1994. Survival curves were constructed using the life table method. Patient data were...

BACKGROUND Nemaline rod disease is a congenital myopathy, presentation of which may mimic myasthenia gravis. METHOD We report a suspected case of nemaline rod disease in a female adolescent who presented with features similar to myasthenia gravis but failed to respond effectively to its conventional management. She had features of respiratory failure and cardiomyopathy. RESULTS Patient had ...

INTRODUCTION Oropharyngeal weakness leading to dysphagia is rarely the presenting symptom of myasthenia gravis, but it can be a significant source of morbidity and mortality. The earliest possible diagnosis of myasthenia gravis should be made for better management of this cause of treatable dysphagia. A detailed evaluation of swallowing by videofluoroscopy can assist in making an accurate diagn...

Anti-acetylcholine receptor (AChR) antibody was undetectable in 26/153 (17%) sera from myasthenia gravis patients assayed by standard RIA using human acetylcholine receptor. Eight of these were found to be positive with a modified protocol using a mixture of normal and denervated AChR, reducing the proportion of "negative" sera to 12%. Many of these were from patients with a short history; two ...

Methods We have analyzed results of surgical treatment of 87 patients having myasthenia gravis. There were 68 (79,2%) female, 19 (21,8%) male. Patients ranged in age from 15 to 64 years. 80 patients (91,9%) had generalized myasthenia, 7 patients (8,1%) had local forms of myasthenia. The most number of patients had IIb – Iva degree of myasthenia according to international clinical classification...

roglobulin, antimicrosome, or antiskeletal muscle autoantibodies whereas the generalised type showed a high titre and incidence of autoantibodies including AChR antibody.5 Seronegative patients or those with low AChR antibody may form a low responder subgroup of myasthenia gravis distinct from the high responders, who show a high titre of AChR antibody. Twelve patients (37 5%) were of the ocula...

Myasthenia gravis and myotonic dystrophy do not usually coexist; however, we present a rare case where both conditions coexisted. Herein, we describe a 34-year-old woman who presented with symptoms of myasthenia gravis with coexisting myotonic dystrophy. She complained of limb weakness, difficulty in chewing and swallowing, and ptosis. She also had myotonia. The patient’s brother also had simil...