INTRODUCTION The primary objective was to evaluate the effect of ad libitum vs. restricted fluid replacement protocol on hydration markers and performance in selected military tasks. The secondary objective was to determine if 300 ml x h(-1) could be considered a safe minimum fluid intake under the experimental conditions. METHODS Data were collected simulating a route march over 16 km. There...

Recent case-control studies reported an association between H. pylori infection and Alzheimer's disease (AD). Our aim was to compare cognitive impairment, neuroinflammation, and cerebrovascular lesion load in a group of AD patients according to their H. pylori status. For the 53 AD patients included, we assessed: clinical data (vascular comorbidities and cognitive assessment), biological data (...

We previously showed that a systemic inhibitor of gp91(phox) (nox2)-based NAD(P)H oxidase abolishes angiotensin II (Ang II)-induced vascular hypertrophy. In the present study, we tested whether perivascular transfection with Ad-gp91ds-eGFP (an adenoviral bicistronic construct targeting NAD(P)H oxidase in fibroblasts) or controls Ad-CMV-eGFP and Ad-scrmb-eGFP would affect medial hypertrophy in r...

BACKGROUND The pathological processes underlying dementia are poorly understood and so are the markers which identify them. Carnosinase is a dipeptidase found almost exclusively in brain and serum. Carnosinase and its substrate carnosine have been linked to neuropathophysiological processes. METHODS Carnosinase activity was measured by a flourometric method in 37 patients attending a Geriatri...

background: the present study examined the possible role of endogenous opioidergic system in effect of food deprivation on formalin-induced nociceptive behaviors in male and female rats. also, we investigated the effect of food deprivation on the plasma level of beta-endorphin and sex hormones. methods: food was withdrawn 48 h prior to performing the formalin test, but water continued to be ava...

AIMS The 24-week, prospective, randomized, double-blind ACTION study investigated the efficacy, safety, and tolerability of 13.3 versus 4.6 mg/24 h rivastigmine patch in patients with severe Alzheimer's disease (AD). METHODS Patients had probable AD and Mini-Mental State Examination scores ≥3-≤12. Primary outcome measures were as follows: Severe Impairment Battery (SIB) and AD Cooperative Stu...

A learner who can solve a problem cannot always understand the problem adequately. In order to deeply understand a problem, it is necessary that he/she poses various problems which can be solved by the “solution method” of the problem. Moreover, after he/she poses problems, it is necessary that he/she considers and indicates differences between the problems posed by him/her, too. So, we develop...

Spanning 30 years and 40 individual videogames across a range of platforms, Pac-Man is one of the most recognizable of all videogame characters and a pop–culture icon. In spite of its widespread popularity, the game receives little sustained academic engagement or analysis. In an attempt to address this, the paper argues that in its classic iterations PacMan generates complex notions of space a...

Paralinguistics organizers such as parenthesis, footnotes, and pop-up fields on screen, should play an important role signalling the writer’s “minimization” intention when secondary points are concerned. This experiment investigated the role of pop-up fields compared to brackets in an information retrieval task. The results showed that, in this kind of task, putting secondary pieces of informat...