Tissue repair and regeneration is an interdisciplinary field focusing on development of biological and bioactive substitutes. Chitosan is a natural polysaccharide exhibiting excellent biocompatibility, biodegradability, affinity to biomolecules, and wound-healing activity. It can also be easily modified via chemical and physical reactions to obtain derivatives of various structures, properties,...

Tissue sealant is a material that used as an adhesive to bond two tissue surfaces during surgery. Chitosan and alginate are natural macromolecules manufacture hydrogels sealants because these materials can strengthen bonds the mechanical properties of sealants.

Porous biopolymer hydrogels doped at 3-6 wt% with 50 nm diameter/0.8 μm long natural clay nanotubes were produced without any cross-linkers using the freeze-drying method. The enhancement of mechanical strength (doubled pick load), higher water uptake and thermal properties in chitosan-gelatine-agarose hydrogels doped with halloysite was demonstrated. SEM and AFM imaging has shown the even dist...

Cytotoxic resin components of common dental bonding agents are known to cause oxidative damage and suppress odontogenic differentiation of dental pulp cells. [1-4] As antioxidants were found to protect cells from cytotoxicity of resin monomers in previous studies,[5-8] we investigated the effects of common antioxidants, such as !-carotene, resveratrol and Vitamin E on anti-differentiation activ...

Peppers are consumed all over the world due to the flavor, aroma, and color that they add to food. Additionally, they play a role in human health, as they contain a high concentration of bioactive compounds and antioxidants. The treatments used were an absolute control, Cs-PVA, and four treatments with 0.02, 0.2, 2, and 10 mg (nCu) g-1 (Cs-PVA). The application of Cu nanoparticles in chitosan-P...

In order to improve the regeneration of full-layer skin defects, hydrogels were developed based on combination chitosan (Cs), Daba silk fibroin (DSF), and graphene oxide (GO): CS, DSF/Cs DSF/Cs/GO. The biocompatibility with human dermis fibroblasts in vitro was evaluated using MTS assay. To assess regenerative potential hydrogels, a model defect reconstructed back rats closed wound surface DSF/...

One of the major, but often overlooked, challenges toward high end applications of nanocelluloses is to maintain their high mechanical properties under hydrated or even fully wet conditions. As such, permanent covalent cross-linking or surface hydrophobization are viable approaches, however, the former may hamper processability and the latter may have adverse effect on interfibrillar bonding an...

Different hydrogels were prepared starting from natural or semi-synthetic polysaccharides (carboxymethylcellulose, hyaluronic acid and chitosan) which were cross-linked by the addition of a cross-linking agent chosen according to the chemical groups present along the polymer chains. The cross-linking reaction allows for the formation of a three-dimensional network made of covalent bonds between...

Mehrdad Yazdani-Pedram,* Cristian Tapia, Jaime Retuert, José Luis Arias Facultad de Ciencias Quı́micas y Farmacéuticas y Centro para la Investigación Interdisciplinaria Avanzada en Ciencia de los Materiales (CIMAT), Universidad de Chile, casilla 233, Santiago, Chile Fax: þ56 2 678 2868; E-mail: [email protected] Facultad de Ciencias Fı́sicas y Matemáticas y Centro para la Investigación Inter...