Promethazine (phenergan) has two methyl groups, which in these derivatives are associated with strong antihistaminic power, while chlorpromazine is a propylamine phenothiazine, which has more marked central nervous system effects but only one-hundredth of the antihistamine potency of promezathine. The Department of Pharmacology at Oxford has pointed out (Burns, 1948; Burns and Dutta, 1948; Dews...

Chlorpromazine and thioridazine are phenothiazines employed in the treatment of psychosis. These agents inhibited the respiration of clinical isolates of Mycobacterium tuberculosis resistant to streptomycin, rifampin, isoniazid, ethambutol and/or pyrazinamid, all first line drugs. Since any adverse reaction to thioridazine is generally less severe than to chlorpromazine, the possibility is attr...

Chlorpromazine-induced agranulocytosis is an uncommon disorder associated with a high frequency of fatality. We describe two patients with chlorpromazine-induced granulocytosis in whom granulocyte colony stimulating factor (G-CSF) administration enhanced the speed of neutrophil recovery. No toxicity was noted with G-CSF and both patients made a successful recovery. We propose there is a role fo...

Struijs PAPAA, Arola H, Assendelft WJJ, et al. Orthotic devices for the treatment of tennis elbow. The Cochrane Database of Systematic Reviews 2002, Issue 1. Art. No.: CD001821. DOI: 10.1002/14651858.CD001821. Struijs PA, Kerkhoffs GM, Assendelft WJ, et al. Conservative treatment of lateral epicondylitis: brace versus physical therapy or a combination of both-a randomized clinical trial. Americ...