background: bone marrow stromal cells (bmsc) are used as a source for cell therapy in different model for neurological disorder such as stroke and spinal cord injury. however, the transdifferentiation of bmsc into cholinergic phenotype requires more investigation. methods: bmsc were isolated from adult rats, pre-induced with β-mercaptoethanol (bme) and followed by nerve growth factor (ngf) indu...

Seizurogenic chemicals include a variety of toxic agents, including chemical warfare agents, toxic industrial chemicals, and natural toxins. Chemical weapons such as sarin and VX, and pesticides such as parathion and carbaryl cause hyperstimulation of cholinergic receptors and an increase in excitatory neurotransmission. Glutamatergic hyperstimulation can occur after exposure to excitatory amin...

It is generally assumed that anticholinergic drugs have no effects on schizophrenic symptomatology. A few studies, however, indicate that anticholinergic agents aggravate psychotic symptoms and antagonize therapeutic effects of neuroleptics in schizophrenic patients; more recently, some investigators have observed that these agents appear to benefit negative symptoms. In an effort to resolve th...

Advances in clinical and basic research methodology combined with clearly articulated concepts create new opportunities for researching the roles of cholinergic mechanisms in the pathophysiology of affective disorders. Areas for study include: 1) roles of cholinergic mechanisms in mediating effects of stress and cholinergic mechanisms linking the pathophysiologies of affective and panic disorde...

Cognitive deficits are major contributors to disability in schizophrenia. Many pharmacologic targets have been identified for cognitive enhancing agents, including receptors involved in dopaminergic, glutamatergic, GABAergic, serotonergic and cholinergic neurotransmission. In addition, new approaches to drug development have been directed towards neuroprotection and the facilitation of neuropla...

results the results showed that bbb test showed an improvement in the cr, while the quantitative analysis showed that the improvement rate was higher in the rats treated with cnl than those treated with bmscs only or the untreated animals, similar results were noticed in the improvement index. immunohistochemical analysis of the tissue section prepared from the cr showed that the transplanted c...

Acetylcholinesterase (AChE) is responsible for hydrolyzing the acetylcholine neurotransmitter, bringing an end point to cholinergic neurotransmission. Thus, AChE primary target of a wide spectrum compounds used as pesticides, nerve agents or therapeutic drugs neurodegenerative diseases such Alzheimer’s disease (AD). This enzyme heterogeneously distributed in brain showing different activity dep...