In a study of spontaneous diseases that occur in albino rats with advance in age, chromophobe adenoma-like lesions were found in the bypophyses of many old rats of the Yale strain. The frequency of this lesion in a limited series of animals, and the prel iminary results of intraocular transplantation of one of the lesions, have been reported (8). Periods of 7 to 12 months elapsed before growth ...

Ik Joon Choi, Sung Hwan Jung, Won Ik Seo, Pil Moon Kang, Soo Jin Jung, Jae Il Chung From the Departments of Urology and Pathology, College of Medicine, Inje University, Busan, Korea The simultaneous occurrence of a renal cell carcinoma and a urothelial carcinoma in the same kidney is uncommon. Here we report the case of a 79-year-old woman with ipsilateral synchronous renal cell carcinoma and u...

OBJECTIVES To evaluate the status of peritumoral pseudocapsules in renal tumors and the effects of clinicopathological factors on their formation. METHODS From January 2011 to December 2012, 258 patients with solitary clinical stage T1a renal tumors who underwent partial nephrectomy were analyzed. Status of pseudocapsule was re-evaluated by a pathologist. RESULTS The mean long diameter (± S...

The pituitary gland is concerned with such diverse functions as growth, sexual activity, carbohydrate and water metabolism, physical energy and the character and distribution of hair. For its size it is a very eloquent structure and although not solely responsible for any of these activities, it has been described as the leader of the endocrine orchestra. Many of its disturbances of function ar...

Neutrophil gelatinase-associated lipocalin (NGAL) is a 25 kDa protein with roles in iron trafficking as well as in carcinogenesis and progression of several human neoplasias. Although the renal proximal tubule represents a major source of NGAL synthesis under various injurious stimuli to the kidney, NGAL expression has been rarely evaluated in renal tumors up to now. In view of this, in the pre...

BACKGROUND Renal cell carcinomas (RCC) are among the most common and most lethal genitourinary malignancies. GOLPH2 (golgi phosphoprotein 2, GOLM1) has recently been proposed as a biomarker for hepatocellular and prostate cancer. In this study we analysed the expression patterns and the prognostic and diagnostic value of GOLPH2 in RCC. METHODS GOLPH2 protein expression was analysed by immunoh...

Chromophobe renal cell carcinoma (ChRCC) is a variant of RCC with certain histological, immunohistological and cytogenetic characteristics. It is believed to arise from the intercalated cells of distal tubules and has a more favourable prognosis than other more common subtypes, clear cell and papillary RCC. Microscopically, neoplastic cells of ChRCC are typically arranged in solid sheets, trabe...

Although the functions of most of the identified microRNAs (miRNAs) have yet to be determined, their use as potential biomarkers has been considered in several human diseases and cancers. In order to understand their role in renal tumorigenesis, we screened the expression levels of miRNAs in four subtypes of human renal neoplasms: clear cell, papillary, and chromophobe renal cell carcinomas (RC...

To evaluate the clinicopathologic features of renal cell carcinoma in younger adults (</=40 years), we retrospectively reviewed 838 consecutive cases of renal cell carcinoma (RCC) occurred in a single tertiary hospital. Forty-four 44 (5.2%) cases occurred in the young adult group (24 to 40 years of age). Clinicopathologic features including tumor size, stage, histologic subtype, lymph node and ...