Inherited defects in DNA repair are rare genetic conditions characterized by hypersensitivity to endogenous and exogenous DNA damage. Double-strand break (DSB) is the most severe form of DNA damage which can induce gross chromosomal rearrangements such as translocations, deletions, duplications, and complex genomic aberrations, triggering permanent cell cycle arrest and, ultimately, the death o...

BACKGROUND Turner syndrome (TS) is a common genetic disorder caused by abnormalities of the X chromosome. We aimed to describe the phenotypic characteristics of TS patients and evaluate their association with presenting clinical characteristics and time at diagnosis. METHODS We studied females diagnosed with TS at King Abdul Aziz Medical City (KAMC), Riyadh between 1983 and 2010. Patients wer...

OBJECTIVE To analyse the progression of body mass index in eating disorders and to determine the percentile for establishment and resolution of the disease. METHODS A retrospective descriptive cross-sectional study. Review of clinical files of adolescents with eating disorders. RESULTS Of the 62 female adolescents studied with eating disorders, 51 presented with eating disorder not otherwis...

This study examines the trends in and determinants of length of postpartum amenorrhea during 1978-90 in Bangladesh. Data are obtained from the Matlab project. The sample comprises 6000 women per cohort for cohorts born in two year periods during 1978-80 and 1988-89. Reproductive and lactation records are available for up to 36 months following the birth of the index child. Findings indicate...

Background: Amenorrhea is defined as the absence of menarche in females reproductive age. Primary amenorrhea failure to reach by age 13 with no secondary sexual characteristics if has not occurred five years after initial breast development or patient 15 older. A transverse vaginal septum a rare congenital abnormality Mullerian duct that can cause primary amenorrhea. Transverse incidence ranges...

3 months and vaginal bleeding following amenorrhea of 3 months' duration and later again after six months. The patient had been married 6 years and had no pregnancy previously. Periods were regular before the last in December 1946. Following this she had amenorrhea for 3 months with usual symptoms of pregnancy (morning sickness, vomiting and frequency of micturition, etc.). Suddenly one day she...