Background . With the increased use of combination antiretroviral therapy, mortality people living with HIV has decreased significantly, which led to an increase comorbidity and secondary HIV-related pathology in both adults also children adolescents infection. The incidence infection those general population varies significantly. aim To assess frequency range chronic comorbidities perinatal Me...

Natural genetic material may shed light on gene expression mechanisms and aid in the detection of disorders. Single Nucleotide Polymorphism (SNP), small insertions deletions (indels), major chromosomal anomalies are all abnormality-related As a result, several methods have been applied to analyze DNA sequences, which constitutes one most critical aspects biological research. Thus, numerous math...

A nonrandom pattern of chromosomal abnormalities occurs in bone marrow cells obtained from patients with hematologic disorders who have an abnormal karyotype involving a C group chromosome. An additional number 8 chromosome is the most common abnormality, found in more than one-half of the patients studies. An additional number 9 chromosome and the loss of all or part of a number 7 are abnormal...

It is known that perinatal mortality is caused in 20-25 percent of cases by inhaerited anomalies of fetuses and many of theese might be explained by genetic disorders. In general genetic disorder is a condition caused by abnormalities in genes or chromosomes. Chromosomes are complex bodies in cell nucleus as carriers of genes. While some diseases are due to genetic abnormalities acquired in a f...

BACKGROUND In Philadelphia-negative chronic myeloproliferative disorders (CMPD), increased proliferation with effective maturation of the myeloid lineage is present, while peripheral leukocytosis, thrombocytosis or elevated red blood cell mass are found. This group of disorders includes polycythemia vera (PV), essential thrombocythemia (ET) and idiopathic myelofibrosis (IMF). Furthermore, cases...

DNA cytophotometry was used to quantify the chromosomal alterations in the bone marrow and blood of three patients with nonspecific myeloid disorders. All patients possessed a population of cells with a morphologically abnormal chromosome 20, del(20)(qll). In two of the patients, the abnormal chromosome 20 showed nearly identical DNA measurements with a net loss of 0.37% of the total autosomal ...